Chronic exposure to inorganic arsenic (In-As) from drinking water is associated with different health effects, including skin, lung, bladder, and kidney cancer as well as vascular and possibly reproductive effects. In-As is metabolized through the process of methylation, resulting in the production and excretion of methylated species, mainly monomethylarsenate (MMA) and dimethylarsenate (DMA). ...

BACKGROUND Depression is concomitantly presented in Hepatitis B Virus (HBV)-infected patients and decreases these patients' quality of life. However, there are no laboratory-based methods to objectively diagnose this disorder. OBJECTIVES The aim of this study was to investigate the alteration of urinary metabolites in depressed HBV-infected patients. PATIENTS AND METHODS In this study, 81 d...

Phthalates, a ubiquitous class of chemicals found in consumer, personal care, and cleaning products, have been linked to adverse health effects. Our goal was to characterize urinary phthalate metabolite concentrations and to identify work and nonwork sources among custodians using traditional cleaning chemicals and 'green' or environmentally preferable products (EPP). Sixty-eight custodians pro...

The reported high anabolic (myotrophic) and low androgenic activity of 19-nortestosterone and its esters in rodents (l-5) prompted an oxperiment to determine whether this substance was useful in human breast cancer as a palliative agent free from virilizing effects. As a result of this experiment it became possible to study its metabolism’ in a human subject. In view of the absence of the angul...

The metabolism of n-tryptophan in man was recently studied by Langner and Berg (l), who found that about one-third to one-half of a 2 gm. dose was excreted unchanged in the urine. Considerable n-kynurenine and traces of indolepyruvic acid and acetyltryptophan were also excreted by their subjecm. Langner and Volkmann (2) found that acetyl-n-tryptophan was poorly absorbed and most of the compound...