PURPOSE To determine whether patients who have acute graft-versus-host disease (AGVHD), are more likely to have radiographically abnormal paranasal sinuses after bone marrow transplantation than patients without AGVHD. METHODS This retrospective case-control study population comprised 45 adult allogeneic or matched unrelated donor patients who underwent bone marrow transplantation. Twenty-eig...

Blastic Plasmacytoid Dendritic Cell Neoplasia (BPDCN) is a rare hematological malignancy whose pathogenesis has not yet been elucidated. Skin, bone marrow, and lymph node involvement can be observed, it generally seen in men old adults. Immunohistochemistry (IHC) features of skin marrow biopsy are essential for diagnosis. There no standardized treatment options this malignancy, the prognosis pa...

chediak - higashi syndrome (chs) is a rare, primary immunodeficiency disorder with an autosomal recessive (ar) inheritance and characterized by re¬current infection, partial occulocutaneous albinism and an accelerated phase. in this report we describe clinical and laboratory findings from 6 chs pa¬tients. clinical and laboratory information of six patients who were referred to our center during...

BACKGROUND With the introduction of novel monoclonal antibody products into the clinic, significant new strategies are being developed to improve upon existing treatment for non-Hodgkin's lymphoma. METHODS Monoclonal antibodies are being used alone, in combination with chemotherapy, or as adjuncts to autologous bone marrow transplantation for the purpose of purging bone marrow of neoplastic c...

Bone marrow transplantation (BMT) has emerged as a major therapeutic option for a number of nonmalignant disorders affecting the bone marrow and leading to clinical manifestations most likely affecting distant organs. Disorders such as autoimmune diseases, metabolic disorders, hemoglobinopathies, immunodeficiencies, and others have been the target of high-dose therapy and autologous or allogene...

Chronic granulomatous disease (CGD) still causes significant morbidity and mortality. The difficulty in considering high-risk yet curative treatments, such as allogeneic bone marrow transplantation, lies in the unpredictable courses of both CGD and bone marrow transplantation in different patients. Some patients with CGD can have frequent infections, granulomatous or autoimmune disorders necess...

B ONE MARROW TRANSPLANTATION may effectively protect dogs exposed to whole-body ionizing radiations of 2 to 3 LD95. Hematopoiesis was investigated at remote periods after the exposure, when the hematopoietic stem cells had been proliferating in the lethally irradiated organism for a long time. Ferrebee and his associates’6 succeeded in attaining long-term survival of supralethally irradiated do...

OBJECTIVE Experimental and clinical studies have suggested that intramyocardial bone marrow stem cell transplantation combined with coronary artery bypass grafting might improve left ventricular function in the setting of chronic ischemic heart disease. We therefore conducted a systematic review and meta-analysis of available publications regarding the efficacy and safety of intramyocardial bon...

Bone marrow mesenchymal stem cell transplantation is an effective treatment for neonatal hypoxic-ischemic brain damage. However, the in vivo transplantation effects are poor and their survival, colonization and differentiation efficiencies are relatively low. Red or near-infrared light from 600-1,000 nm promotes cellular migration and prevents apoptosis. Thus, we hypothesized that the combinati...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...