Spinal motor neurons (MNs) and V2 interneurons (V2-INs) are specified by two related LIM-complexes, MN-hexamer and V2-tetramer, respectively. Here we show how multiple parallel and complementary feedback loops are integrated to assign these two cell fates accurately. While MN-hexamer response elements (REs) are specific to MN-hexamer, V2-tetramer-REs can bind both LIM-complexes. In embryonic MN...

This paper presents BOOM version 2, an updated version of the Berkeley Out-of-Order Machine first presented in [3]. The design exploration was performed through synthesis, place and route using the foundry-provided standard-cell library and the memory compiler in the TSMC 28 nm HPM process (high performance mobile). BOOM is an open-source processor that implements the RV64G RISC-V Instruction S...

We investigated the pressure driven flow of concentrated colloidal dispersions in a converging channel geometry. Optical microscopy and image analysis were used to track tracer particles mixed into dispersions of sterically stabilized poly(methyl methacrylate) (PMMA) spheres. The dispersions were drawn into a round 0.5 mm capillary at one of two pump speeds (^ applied pressure): v1 1⁄4 0.245 ml...

Let f be a proper k-coloring of a connected graph G and Π = (V1, V2, . . . , Vk) be an ordered partition of V (G) into the resulting color classes. For a vertex v of G, the color code of v with respect to Π is defined to be the ordered k-tuple cΠ(v) = (d(v, V1), d(v, V2), . . . , d(v, Vk)), where d(v, Vi) = min{d(v, x) : x ∈ Vi}, 1 ≤ i ≤ k. If distinct vertices have distinct color codes, then f...

We investigated psychophysically whether feature-based attention modulates the perception of figure-ground (F-G) segregation and, based on the results, we investigated computationally the neural mechanisms underlying attention modulation. In the psychophysical experiments, the attention of participants was drawn to a specific motion direction and they were then asked to judge the side of figure...

Abstract Vitiligo is a chronic autoimmune disease that targets melanocytes, causing skin depigmentation. Disease pathogenesis largely regulated by interferon-? activation of the Janus kinase (JAK) signalling pathway. A cream formulation JAK1/JAK2 inhibitor ruxolitinib demonstrated substantial re-pigmentation in two randomized, double-blind, vehicle-controlled phase 3 studies adults and adolesce...

This study investigates how child speakers of a verb second (V2) language acquire the supposedly more basic SVO word order of English. Data comes from approximately 100 Norwegian school children aged 7 to 12 in their acquisition of three related syntactic constructions. The focus of the investigation is the extent of language transfer from the L1, related to questions of markedness. It is shown...

We present the elliptic flow v2 of pions produced from resonance decays. The transverse momentum pT spectra of the parent particles are taken from thermal model fits and their v2 are fit under the assumption that they follow number-of-constituent-quark (NCQ) scaling expected from quark-coalescence models. The v2 of pions from resonance particle decays is found to be similar to the measured pion...