Ni les débats parlementaires ni la décision du Conseil constitutionnel 21 janvier 2022 (n° 2022-835) n'ont soulevé question de libre disposition corps et consentement aux soins dans mise en œuvre « passe vaccinal ». Le législateur entretient pourtant un flou juridique quant contours cette mesure à son caractère contraignant. En l'absence d'une obligation vaccinale formelle, il est possible s'in...

The use of yellow fever (YF) virus 17D strain for vaccine production adapted in Brazil since its introduction in 1937 was reviewed. This was possible due to the availability of official records of vaccine production. The retrieved data highlight the simultaneous use of several serially passaged 17D substrain viruses for both inocula and vaccine preparation that allowed uninterrupted production....

BACKGROUND Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira species. A major challenge of this disease is the application of basic research to improve diagnostic methods and related vaccine development. Outer membrane proteins of Leptospira are potential candidates that may be useful as diagnostic or immunogenic factors in treatment and analysis of the disease. OBJECTIVES...

Anaplasma marginale (A. marginale) has a remarkable impact on livestock production, and an effective vaccine is not currently available due to the inexistence of a small animal model. Recently, BALB/c mice were successfully infected with A. marginale, resulting in an acute and persistent anaplasmosis infection. Here, we designed a hybrid protein containing repeats of polypeptide 1a from major s...

We have shown that it is possible to obtain from extracts of vaccine virus-infected tissues a substance or substances, apparently protein, which are serologically active, and which are specifically related to vaccinal infection. The present investigation is concerned with a study of their immunological reactions. Their intraperitoneal injection in rabbits is followed by the appearance in the se...

INTRODUCTION Leptospirosis, caused by infection with pathogenic Leptospira species, is one of the most prevalent zoonotic diseases in the world. Current leptospiral vaccines are mainly multivalent dead whole-cell mixtures made of several local dominant serovars. Therefore, design and construction of an efficient recombinant vaccine for leptospirosis control is very important. OmpL1 is an immuno...

The potential for vaccines to act as triggers of autoimmune reactions has received much recent attention. Such an association is very poorly defined mechanistically, but may potentially involve epitope mimicry between vaccinal and self antigen, or the immuno-stimulatory effects of vaccine adjuvant. If such reactions occur, they are more likely to involve adults than infants in early life, as a ...

Le tétanos est évitable par la vaccination, mais peut survenir en cas d’une immunisation incomplète. Nous avons mené une étude sur les dossiers médicaux des enfants admis pour tétanos entre 2008-2009 au Centre Mère et Enfant de la Fondation Chantal BIYA à Yaoundé. Le but était d’analyser les circonstances de survenue et les manifestations cliniques du tétanos chez le grand enfant, afin de propo...

Since its introduction into northern Europe in 2006, bluetongue has become a major threat to animal health. While the efficacy of commercial vaccines has been clearly demonstrated in livestock, little is known regarding the effect of maternal immunity on vaccinal efficacy. Here, we have investigated the duration and amplitude of colostral antibody-induced immunity in calves born to dams vaccina...