Objectives: to compare the clinical effectiveness, side effects and tolerability of rectal versus vaginal bromocreptine/pluronic F-127suppositories as compared to oral bromocriptine tablets for treating pathologic hyperprolactinemia. Design: An active comparator randomized study. Setting: A pharmaceutical phase at the department of Pharmaceutics, Faculty of Pharmacy, and a clinical phase at the...

this study a novel High Performance Liquid Chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using Box–Behnken experimental design. The method was performed in the isocratic mode on a RP-18 column (30 °C) using a mobile phase consisting of 0.05 M ammonium acetate buffer/ Methanol mixture (30:70) and a flow-rate of 1.0 ml/min. The method was valida...

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Mucoadhesive vaginal tablets of tenofovir disoproxil fumarate (TDF) have been formulated using hydroxypropyl methylcellulose (HPMC K100) as the matrix forming retarding agent with various mucoadhesive polymers such as carbopol 934, 940, chitosan and sodium carboxymethylcellulose and evaluated. Wet granulation method was employed to make the tablets. Drug-excipient compatibility, precompression ...

Postpartum hemorrhage (PPH) is the commonest cause of maternal death worldwide. Studies suggest that the use of misoprostol may be beneficial in clinical settings where oxytocin is unavailable. The aim of this study was to compare the safety and efficacy of oxytocin and misoprostol when used in the prevention of PPH. In a double-blind randomized controlled trial, 400 pregnant women who had a va...

Case report A Parses girl, aged 18, was treated last year for typhoid fever. She ran a continuous fever ranging from 99?F. to 106?F. for a period of about two months before succumbing finally to a toxic myocarditis and intestinal haemorrhage. It was during the fifth week of fever that she presented symptoms and signs of a vitamin deficiency. She started complaining of a 'raw feeling' in the mou...