This paper describes the Department for Education and Skills' (DfES) practical approach to tackling meta-data and surrounding issues. A metadata pilot project was set up by the Library and Information Services Team to develop a metadata scheme for departmental use. Using the Dublin Core based e-Government Metadata Standard (e-GMS), Library staff developed a draft metadata standard for departmen...

PURPOSE To investigate the feasibility of adaptive dosing and the impact of pharmacogenetic variation on 13-cis-retinoic acid (13-cisRA) disposition in high-risk patients with neuroblastoma. EXPERIMENTAL DESIGN 13-cisRA (160 mg/m(2) or 5.33 mg/kg/d) was administered to 103 patients ages 21 years or less and plasma concentrations of 13-cisRA and 4-oxo-13-cisRA quantitated on day 14 of treatmen...

The blood thinner warfarin has a narrow therapeutic range and high inter- and intra-patient variability in therapeutic doses. Several studies have shown that pharmacogenomic variants help predict stable warfarin dosing. However, retrospective and randomized controlled trials that employ dosing algorithms incorporating pharmacogenomic variants under perform in African Americans. This study sough...

Background: MUTYH DNA glycosylase germline mutations are linked to the recessive inheritance of multiple adenoma. Studies have revealed that germline mutations in this gene are ethnicity related. This study aimed to identify the germline mutations in MUTYH gene and determine their prevalence among Jordanian patients with colorectal adenoma. Methods: In this study, 150 colorectal adenoma patient...

Background: Recurrent pregnancy loss (RPL) is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of heterochromatin polymorphism in couples with recurrent miscarriages compared with couples without miscarriages. Materials and Methods: Over a 3 year period, we made a study of the diagno...

Diblock PEG-p(CL-co-TMC) [methoxypoly(ethylene glycol)-poly(caprolactone/trimethylene carbonate)] copolymers form micelles spontaneously and significantly increase the solubility of poorly water-soluble drugs. The aim of this work was to assess these diblock copolymers as oral drug delivery systems in both in vitro and in vivo experiments using risperidone as a model drug. The permeation of ris...

This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the pharmacokinetic profile and therapeutic efficacy of PX after intramuscular (IM) injection. In the pharmacokinetic study in rats, systemic exposure and pharmaco...

Abstrakt: Dieser Beitrag ist ein Bericht über die Transformation von IBM-Assembler Code in ANSICOBOL-85. Es ging um ein Proof of Concept Projekt zu erforschen in wie fern diese Umsetzung automatisierbar ist. Neben der Restrukturierung und der Umsetzung der Assembler Prozeduren sollten auch die Daten in ein zentrales Datenverzeichnis gesammelt und umbenannt werden. Das Ziel war eine Basis zu sch...

Die computerlinguistische Arbeit am Text (Textanalyse, Textgenerierung, Information Retrieval innerhalb von Texten) verlangt nicht nur Festlegungen hinsichtlich der Repräsentationen und Verfahren, sondern setzt konzeptuelle Arbeit hinsichtlich des Gegenstands und der Zwecksetzung der anvisierten Computerprogramme voraus. Im weiteren scheint es im immer noch recht jungen Bereich textorientierter...