The use of BNP as a diagnostic and therapeutic tool in the management of heart failure is promising. Additional studies need to be done regarding the use of BNP as a diagnostic tool to clarify its intrapatient and interpatient variability, especially over time. Nesiritide is the first new intravenous agent for the treatment of acute decompensated heart failure since the introduction of milrinon...

This paper presents a method for bioassay of vasotropic substances. Data on the accuracy of the method are presented in terms of the response to repeated injections of methacholine. Some of the factors affecting the response to methacholine are analyzed. The peripheral vasodilator effect of a nondialyzable substance present in human urine is demonstrated and the effectiveness of this substance ...

This paper presents a method for bioassay of vasotropic substances. Data on the accuracy of the method are presented in terms of the response to repeated injections of methacholine. Some of the factors affecting the response to methacholine are analyzed. The peripheral vasodilator effect of a nondialyzable substance present in human urine is demonstrated and the effectiveness of this substance ...

Coronary vasodilating activity of chromone derivatives has been reported.2) It is worth examining if chromanone derivatives have a coronary vasodilating effect, since they are chemically related to chromone. In the present study the effects of some benzylidene chromanones and its related compounds on coronary blood flow and myocardial oxygen consumption in anesthetized dogs and also on the oxyg...

Cerebral blood flow (CBF) was measured before and after intravenous injection of the cerebral vasodilator nicergoline in 13 patients with cerebrovascular disease. CBF increased in seven. The possibility that the effect of the drug in the remainder may have been masked by a fall of CBF which occurs during sequential measurement of patients at rest is discussed.

Original Article Pregnancy-induced hypertension (PIH), Vasopressor, Vasodilator, Nitric oxide.

Jennifer M Sasser,* Marshall D. Lindheimer, and Chris Baylis* *Department of Physiology and Functional Genomics, Department of Medicine, Division of Nephrology, University of Florida, Gainesville, Florida; Departments of Obstetrics & Gynecology and Medicine, and the Committee on Clinical Pharmacology, University of Chicago, Chicago, Illinois J Am Soc Nephrol 17: 2960–2961, 2006. doi: 10.1681/AS...

FK409 (1), a novel vasodilator, is a semi-artificial fermentation product of Streptomyces griseosporeus No. 16917, which was cultured in a medium containing nitrate. And the acid-treatment of the broth is essential for the generation of FK409. FK409 was considered to be formed via a novel synchronous nitrosation-nitration reaction of FR-900411 (2) which was produced by the strain as a precursor...

Because hypertension and myocardial infarction are closely linked in several ways, a better understanding of this relation leads to more effective prophylaxis and management. Management should be directed at three different areas: 1) the prevention of a first myocardial infarction, 2) the prevention of complications after an infarction, and 3) the management of hypertension during evolution of ...

Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a fundamental role in matching microvascular oxygen supply with local tissue oxygen demand. Signal transduction within the erythrocyte and microvessels as well as feedback mechanisms controlling ATP release have been described. Our understanding of the impact of this novel control mechanism will rely on the in...