There is a rise in the concurrent use of methylphenidate (MPH) and fluoxetine (FLX) in pediatric populations. However, the long-term neurobiological consequences of combined MPH and FLX treatment (MPH FLX) during juvenile periods are unknown. We administered saline (VEH), MPH, FLX, or MPH FLX to juvenile Sprague Dawley male rats from postnatal day 20 to 34, and assessed their reactivity to rewa...

Elevated levels of an endogenous ouabain circulate in many patients with essential hypertension. However, in contrast to ouabain, digoxin does not induce hypertension. This study investigated the hypothesis that within a single cardiac glycoside, the structural elements that induce hypertension differ from those responsible for high potency as a sodium pump inhibitor. Normal male Sprague-Dawley...

Preexistent cardiopulmonary disease in humans appears to enhance susceptibility to the adverse effects of ambient particulate matter. Previous studies in this laboratory have demonstrated enhanced inflammation and mortality after intratracheal instillation (IT) and inhalation (INH) of residual oil fly ash (ROFA) in a rat model of pulmonary hypertension induced by monocrotaline (MCT). The presen...

BACKGROUND Although considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens in motivation for cocaine during early stages of addiction, less is known with regard to its role after the development of addiction. Here, we examined its role in the development of an addicted phenotype in intact male and female rats, and in female rats that were either resistant or vu...

Urban aerosol sources are important due to the health effects of particles and their potential impact on climate. Our aim has been to quantify and parameterise the urban aerosol source number flux F (particles m−2 s−1), in order to help improve how this source is represented in air quality and climate models. We applied an aerosol eddy covariance flux system 118.0 m above the city of Stockholm....

BACKGROUND Genistein has high estrogenic activity. Previous studies have shown beneficial effects of estrogen or hormone replacement therapy on muscle mass and muscle atrophy. OBJECTIVE We investigated the preventive effects and underlying mechanisms of genistein on muscle atrophy. METHODS In Expt. 1, male Wistar rats were fed a diet containing no genistein [control (CON)] or 0.05% genistei...

Multicarrier energy systems create new challenges as well opportunities in future systems. One of these is the interaction among multiple and hubs different markets. By advent local thermal market many countries, hubs' scheduling becomes more prominent. In this article, a approach to offered, called virtual hub (VEH). The proposed concept hub, which named VEH referred an architecture based on b...

We investigated the effect of administration of somatotropin (ST) and/or eCG on insulin-like growth factor I (IGF-I) and IGF-binding proteins (IGFBP) in serum and follicular fluid (FFL) of cattle actively immunized against growth hormone-releasing factor (GRF). Cyclic beef cattle, previously immunized against GRF-(1-29)-Gly-Gly-Cys-NH2 conjugated to human serum albumin (synthesized and provided...

Vibration energy harvesters (VEHs) allow the extraction of ambient mechanical energy. The proposed analysis focuses on bistable with Duffing nonlinearity. Bistable exhibit larger frequency bandwidth than linear monostable harvesters, but they complex behaviors (i.e., multiple periodic orbits and chaos), making their evaluation challenging. To assess quality a VEH, it is necessary to evaluate it...

We postulated that the combination of overexpression of CXCR4 in mesenchymal stem cells (MSC) with diprotin A would enhance MSC recruitment and penetration into ischemic myocardium, leading to an improvement in heart function after myocardial infarction (MI). Male rat MSC were genetically engineered with adenoviral vectors coexpressing CXCR4 and enhanced green fluorescent protein (EGFP) (MSC(CX...