Verrucous epidermal nevi are congenital hamartomas composed of keratinocytes and may occur alone or in association with developmental abnormalities. A close relationship between variations in the PIK3CA and FGFR3 genes and the appearance of nevi has been recently reported. Based on that, we performed molecular assays for the identification of E542K, E545G/K and H1047R mutations in the PIK3CA ge...

Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneou...

The subject case of this report is a 22-year-old female patient with Verrucous Linear Epidermal Nevus (VLEN) who underwent Er:YAG laser resurfacing. The lesion unilaterally affected the external side of the upper left arm from the cubital space to shoulder, the left mammary region, the left neck region, and the left part of the back from the shoulder to the gluteal region. Several dermatologica...

Submit Manuscript | http://medcraveonline.com it may present itself (Proteus in Greek means polymorph), being an extremely rare disease: about 200 cases have been described worldwide, with about 120 being alive [3]. Characterized by pigmented verrucous nevus and thickening of the skin, lipomas, hemangiomas, hemihypertrophy, gigantism of the extremities (hands and feet), visceral abnormalities a...

BACKGROUND Bullous congenital ichthyosiform erythroderma (BCIE) shows phenotypic variability. An epidermal nevus may represent somatic mosaicism for keratin gene mutation, which produces generalized BCIE in the next generation. This fact provides evidence that a postzygotic mutation can be passed on to the next generation in BCIE. We hypothesized that the same phenomenon occurred in a family wi...

A 59-year-old male visited our department, complaining of red itchy papules on his right lower leg. Initially, the papules appeared on the dorsum of his right foot, and spread upwards to the shin. He had no infectious symptoms, such as throat pain and fever, prior to the development of the dermatosis. Physical examination revealed that a number of reddish papules and erythematous lesions with s...

Becker's nevus, also called Becker's melanosis or pigmented hairy epidermal nevus, is a benign cutaneous hamartoma characterized by hyperpigmented macule usually with hypertrichosis. It is rarely associated with neurofibromatosis. We report a 2 1⁄2 yrs old male child with coexistent congenital Becker’s nevus and type 1 neurofibromatosis.

Background: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays an immunomodulatory role in a variety of systemic and dermatologic disease. Its blockade can be achieved by using specific inhibitors like etanercept. At present, etanercept is approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis and psoriasis treatme...