نتایج جستجو برای: vertical coplanar vcp
تعداد نتایج: 99181 فیلتر نتایج به سال:
Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encoding CAG expansion in the ATXN3 gene, which encodes a 42 kDa deubiquitinating enzyme (DUB), ataxin-3...
The initial aim of this study was to identify novel serum diagnostic markers for the human ovarian granulosa cell tumor (GCT), a tumor that represents up to 5% of all ovarian cancers. To circumvent the paucity of human tissues available for analyses, we used the Ctnnb1(tm1Mmt/+);Pten(tm1Hwu/tmiHwu);Amhr2(tm3(cre)Bhr/+) transgenic mouse model, which features the constitutive activation of CTNNB1...
The response of eukaryotic cells to DNA damage includes the activation of phosphatidylinositol-3 kinase-related kinases (PIKK), such as ATM, ATR, and DNA-dependent protein kinase (DNA-PK). These three kinases have very similar substrate specificities in vitro, but in vivo, their substrates overlap only partially. Several in vivo substrates of ATM and ATR have been identified and almost all of t...
The discovery of effective therapies and of disease mechanisms underlying valosin containing protein (VCP)-associated myopathies and neurodegenerative disorders remains elusive. VCP disease, caused by mutations in the VCP gene, are a clinically and genetically heterogeneous group of disorders with manifestations varying from hereditary inclusion body myopathy, Paget's disease of bone, frontotem...
Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components. A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity. The structure of VCP reveals a highly extended molecule with a putative heparin recognit...
In this article, a new CAD model for the coplanar waveguide (CPW) cross-over air-bridge is proposed. The model takes into account the CPW open-end capacitance and the vertical strips of the bridge. The section directly underneath the bridge is modeled as a small section of a microstrip line. Our results are in good agreement with the published full-wave results. © 2005 Wiley Periodicals, Inc. I...
Hypertension-induced left ventricular hypertrophy (LVH) is an independent risk factor for heart failure. Regression of LVH has emerged as a major goal in the treatment of hypertensive patients. Here, we tested our hypothesis that the valosin-containing protein (VCP), an ATPase associate protein, is a novel repressor of cardiomyocyte hypertrophy under the pressure overload stress. Left ventricul...
INTRODUCTION Hereditary inclusion body myopathy (IBM) with Paget’s disease of the bone (PDB) and frontotemporal dementia (FTD) (IBMPFD) is a rare autosomal dominant disorder due to mutations in the valosin-containing protein gene (VCP). Pathogenic VCP variants have also been associated with amyotrophic lateral sclerosis and other phenotypes including dilated cardiomyopathy and Parkinson’s disea...
Previously, a pneumatic design of fingertip haptic device (FHD) was developed for virtual reality applications. In this paper, the feasibility representing tissues varying stiffness is investigated. Physical properties, and Young’s modulus variable compliance platform (VCP) were compared with set bolus materials soft tissues. moduli ten times higher than those from VCP, whereas fairly similar. ...
Granzyme K (GzmK) highly expressed in NK and NKT cells. We recently demonstrated that GzmK induces rapid caspase-independent cell death with ssDNA nicks. Little is known about its molecular mechanisms to mediate caspase-independent cell death. In this study, we found the valosin-containing protein (VCP) is a physiological substrate of GzmK. GzmK cleaves VCP at residue Arg(713) in the D2 domain ...
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