Hereditary cerebral hemorrhage with amyloidosis - Dutch type is an autosomal dominant hereditary disease caused by a point mutation in the amyloid precursor protein gene on chromosome 21. The mutation causes an amino acid substitution at codon 693 (E22Q), the 'Dutch mutation'. Amyloid β, the product after cleavage of the amyloid precursor protein, is secreted into the extracellular space. The D...

Vasculitides are a group of syndromes marked by inflammation and necrosis of blood vessels of various calibres, with luminal impairment and ischemiainduced changes in the tissues supplied (Hunder et al, 1996; Rao et al, 1998; Jennette et al, 1994). Vasculitis was first recognised as a disease in 1801 when Heberden described a case in a fiveyear-old child. Further descriptions were provided by S...

We describe a mathematical/computational model for thrombin concentration gradients generated by procoagulant circulating tumor cells (CTCs) in flow. We examine how CTCs enhance blood coagulation as they diffuse tissue factor-dependent coagulation enzymes in a flow environment with vessel walls. Concentration fields of various enzymes, such as prothrombin and thrombin, diffuse, to, and from CTC...

BACKGROUND Pityriasis lichenoides is a papulosquamous disorder of unknown etiology with remissions and exacerbations. Histopathology helps greatly in the diagnosis of this condition. AIM We studied clinical and histopathological features of pityriasis lichenoides in our patients. METHODS This is a 3-year retrospective and prospective, descriptive study of all patients clinically diagnosed a...

In the central nervous system, endothelial cells (ECs) and pericytes (PCs) of blood vessel walls cooperatively form a physical and chemical barrier to maintain neural homeostasis. However, in diabetic retinopathy (DR), the loss of PCs from vessel walls is assumed to cause breakdown of the blood-retina barrier (BRB) and subsequent vision-threatening vascular dysfunctions. Nonetheless, the lack o...

During the contraction of the heart from the heart along the walls of the blood vessels, a wave of pressure propagates, which is called a pulse wave. As the wave moves away from the heart, this wave gradually weakens and practically fades in the capillaries. The speed of the pulse wave propagation depends on many factors, among which, for example, the elastic-viscous properties of the vessel wa...

Background: Recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 Gy can reduce rate of restenosis in patients who have undergone an angioplasty. The use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. Materials and Methods: The Monte Carlo N-particle Transport Code (MCNP4b) was used...