The picture of itching, sneezing and profuse rhinorrhoea is typical of early allergic rhinitis, but nasal obstruction becomes more prominent over time, especially in perennial allergic rhinitis. This gives rise to the classic facial appearance of children with perennial allergic rhinitis and to the many complications. The most effective therapy for allergic rhino-sinusitis involves topical nasa...

Respiratory syncytial virus (RSV) bronchiolitis causes severe respiratory tract infection in infants, frequently necessitating mechanical ventilatory support. However, life-saving, mechanical ventilation aggravates lung inflammation. We set up a model to dissect the host molecular response to mechanical ventilation in RSV infection. Furthermore, the response to induced hypercapnic acidosis, rep...

The purpose of this study was to evaluate the viral frequency, seasonality, and clinical and demographic features of patients hospitalized with acute bronchiolitis. A cross-sectional, descriptive study was performed in 316 infants younger than 2 years of age who were hospitalized for acute viral bronchiolitis. Respiratory tract infection agents were investigated with polymerase chain reaction (...

Over 200 strains of respiratory viruses cause a variety of human infections ranging from common cold to life-threatening pneumonia. Respiratory viruses implicated in this study are respiratory syncytial viruses (RSV), adenovirus, influenza viruses and parainfluenza viruses. The objective of this study is to determine the epidemiology of respiratory viruses in paediatric patients with lower resp...

issue of Respiration, Gencay et al. [1] used serology for a panel of 8 common human viruses (adenovirus, enterovirus, influenza viruses A and B, parainfluenza viruses 1, 2 and 3, and respiratory syncytial virus) to document evidence of acute viral infection in patients diagnosed with LRTI. Major endpoints studied included: comparison of the proportion of individuals showing positive viral serol...

The hypothesis that the prone sleeping position is associated with accumulation of upper airways secretions and increased bacterial growth was investigated in adults. Ten subjects with upper respiratory tract infection lay prone for one hour and then supine for one hour. Nasal swabs after the prone period yielded higher bacterial counts than swabs obtained after the supine period. This result c...

Respiratory viruses are frequently detected in adult patients admitted to the intensive care unit (ICU) and are increasingly being recognised for their role as causal agents in severe respiratory tract infections. Diagnostic sensitivity and time to result have greatly improved with the advent of molecular diagnostics. However, the burden of viral respiratory tract infections in adults remains u...

OBJECTIVE To review the available literature on the association between acute viral respiratory tract infection and the onset of asthma exacerbations, identifying the most prevalent viruses, detection methods, as well as preventive and therapeutic aspects. SOURCES A search was conducted in PubMed, Lilacs, and SciELO databases, between the years 2002 and 2013, using the following descriptors: ...

Bovine herpesvirus (BoHV) type 1 is an important agricultural pathogen that infects cattle and other ruminants worldwide. Acute infection of the oro-respiratory tract leads to immune suppression and allows commensal bacteria to infect an otherwise healthy lower respiratory tract. This condition is known as the Bovine Respiratory Disease (BRD). BoHV-1 latently infects the host for life and perio...

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive M...