BACKGROUND Dengue is a major public health problem in tropical and subtropical countries. Exploring the relationships between virological features of infection with patient immune status and outcome may help to identify predictors of disease severity and enable rational therapeutic strategies. METHODS Clinical features, antibody responses and virological markers were characterized in Vietname...

Detection of anti-hepatitis C virus (anti-HCV) antibodies may yield a high frequency of false-positive results in people at low risk. To date, no clinical rule had been developed to predict viremia in HCV-seropositive patients. Therefore, we aimed to generate a prediction rule on the basis of clinical and serologic data, which can be used in outpatient care. We selected 114 seropositive patient...

The immune system, an exquisitely regulated physiological utilizes a wide spectrum of soluble factors and multiple cell populations subpopulations at diverse states maturation to monitor protect the organism against foreign organisms. Immune surveillance is ensured by distinguishing self-antigens from self-associated with non-self (e.g., viral) peptides presented major histocompatibility comple...

Background: Globally the benefits of undetectable viremia in preventing transmission HIV/AIDS have been established.
 Objective: The study aimed to assess prevalence and determinants viral load amongst clients receiving care treatment RISE-supported facilities Akwa Ibom State, Nigeria.
 Methods: A descriptive cross-sectional was conducted using secondary data from a validated Retentio...

Patients who receive stem cell transplantation (SCT) can develop cutaneous eruptions with systemic involvement such as graft versus host disease (GVHD), drug hypersensitivity syndrome (DIHS), or viral exanthema. These conditions often have overlapping clinical and laboratory presentations may be associated risk factors reactivation medications. In this study, we evaluated the incidence, present...

Human oral squamous cell carcinomas (hSCCs) are the most common head and neck cancers now presenting with more aggressive biological clinical features due to smoking alcohol together widespread viremia. Transforming growth factor-β (TGF-β) proteins powerful morphogens that induce rapid substantial induction of endochondral bone formation but in primates only.

In dengue virus infections the asymptomatic cases are much more frequent than the symptomatic ones, but their true role in the introduction and subsequent spread of dengue viruses in non-endemic regions remains to de clarified. We analyzed data from English and French literatures to assess if viremia in asymptomatic dengue infections might be sufficient to represent a true risk. During outbreak...

Modified, human immunodeficiency virus (HIV)-inoculated thy/liv-SCID-hu mice were used to evaluate the in vivo efficacy of antiretroviral drugs. Ritonavir treatment alone initially suppressed plasma viremia, but the viremia recurred with the appearance of ritonavir-resistant HIV isolates. Multidrug therapy suppressed plasma HIV RNA to undetectable levels; however, plasma viremia returned after ...