Lewis y is a difucosylated oligosaccharide carried by glycoconjugates on the cell surface. Elevation of Lewis y is frequently observed in epithelial-derived cancers. This study aimed to detect the expression and clinical significance of the Lewis y antigen and TGF-β1 (transforming growth factor β1) in ovarian epithelial tumors, and to evaluate the correlation between them. Immunohistochemical s...

Non-epithelial malignancies of the ovary account for 10% of all ovarian cancers. Germ cell tumors (GCTs) are diagnosed principally in young subjects whereas sex cord stromal tumors (SCSTs) are more common in adult women. GCTs represent 5% of all ovarian neoplasms and 80% of preadolescent malignant ovarian tumors. Sex cord stromal tumors are rare neoplasms that account for 3–5 % of ovarian malig...

Background: Teratomas are the most common ovarian germ cell tumors. Growing teratoma syndrome is a rare condition that entails appearance of extragonadal teratomas during or after chemotherapy treatment non seminomatous

AIM The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. METHODS We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in ...

Other rare ovarian causes of hyperandrogenism include gynandroblastoma, gonadoblastoma, ovarian carcinoid, surface epithelial tumors (Brenner tumor) and metastatic tumors [5]. These tumors are rare representing only 10% of all ovarian tumors. Tumoral cause of hyperandrogenism is suspected when the serum testosterone levels are significantly elevated (>200 ng/ml), rapidly progressive symptoms of...

Background: Mature cystic teratoma of the ovary is one of the most common benign ovarian tumors, which may be confused with other adnexal lesions due to its extensive manifestations on ultrasound. Therefore, in this study, we tried to reduce the need for pathology frozen sections by examining more accurate preoperative ultrasound results and classifying ovarian lesions based on them. Methods: ...

OBJECTIVE The recently cloned gene p16 (MST1) has been identified as a putative tumor suppressor gene that binds to CDK4 and CDK6 (cyclin-dependent kinases), preventing their interaction with cyclin D1 and thereby preventing cell cycle progression at the G1 stage. In addition, the p16 gene has been shown to have a high frequency of mutation in some tumor cell lines; however, it has also been sh...

Throughout the animal kingdom the solid ovarian tumors seem to be infrequent, as they also are, relatively, among human tumors. Cystic tumors are described occasionally, but apparently less frequently in the lower animals than in man. Even among dogs, with their high incidence of tumor growth, ovarian tumors are rare according to the evidence furnished by literature dealing with canine neoplasm...

Advanced ovarian cancer is a devastating disease. Gaining biomarkers of early detection during ovarian tumorigenesis may lead to earlier diagnosis and better therapeutic strategies. Cystatin B (CSTB) functions as an inhibitor to suppress intracellular cysteine proteases and has been implicated in several types of cancers. The present study explored the expression of CSTB in human ovarian tumors...