Vitiligo is an acquired depigmentary skin disorder characterized by white maculae on the skin associated with social stigma. Vitiligo has major impact on the quality of life due its high cosmetic value, chronic nature of disease and long term ineffective treatments. Vitiligo patients suffer from low self-esteem and poor body image that affects their emotional and psychological well-being. To in...

INTRODUCTION Vitiligo is an acquired idiopathic depigmentary disorder, which, though worldwide in distribution, is very common in India, Egypt and other tropical countries. While patients become desperate, develop a complex and social ostracism, a conscientious physician feels guilty because of his limitations. Though various aspects of vitiligo have been extensively studied, its etiopathogenes...

BACKGROUND Limited data are available on the association between vitiligo and autoimmune thyroid disease in pediatric patients. In addition, reported studies of pediatric patients have been based on a population known to have vitiligo and subsequently evaluated for the presence of thyroid function abnormalities. METHODS A retrospective chart review was performed on 333 children who had been f...

Vitiligo is an acquired skin disorder characterized by patchy depigmentation of the skin [1]. Vitiligo affects approximately 0.5% to 2% of the population worldwide, and the prevalence appears to be equal between men and women [2,3]. The pathogenesis of vitiligo is still not fully understood and mounting evidences have suggested that it might be related to autoimmunity and oxidative stress [4]. ...

Vitiligo is a complex genetic skin depigmentation disorder caused by the destruction of melanocyte from the lesional site. Liver X Receptor-α (LXR-α) expression is upregulated in the melanocytes from perilesional skin as compared to the normal skin of vitiligo patient suggesting its involvement in vitiligo pathogenesis. Polymorphisms in LXR-α have been associated with several diseases including...

BACKGROUND It was previously thought that persons with genetic predispositions to vitiligo develop the condition after exposure to various precipitating environmental factors. However, in many cases, the aggravating factors of vitiligo have not been clearly identified. OBJECTIVE To identify the aggravating factors of vitiligo in the working environment and daily life. METHODS A total of 489...

Background: Atopy is according to some authors frequently accompanying vitiligo. We investigated the problem in a series of patients. Materials and Methods: 64 vitiligo patients and 58 controls of a similar age and sex distribution participated in the study. Detailed histories concerning the atopic diseases and total serum IgE levels were obtained. These findings were assessed considering also ...

Background: Vitiligo is characterized by selective destruction of melanocytes. Transforming growth factor beta 1 (TGFβ 1) is the main product of regulatory T cells (Tregs) which are deficient in vitiligo. Thus, lower levels of serum TGFβ 1 are expected in vitiligo. However, TGFβ 1 is a keratinocytederived cytokine with inhibitory effect on melanocyte activity. Thus it may be expected to be high...

© 2018 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Sir, Vitiligo is an idiopathic depigmentory skin disorder.[1] One of the first clues for the involvement of cellular immunity in the pathogenesis of vitiligo was the discovery of T‐cell infiltration in the margins of vitiligo skin lesions.[2] Furthermore, increased production of interleukin (IL)‐6, IL‐8 and tumor nec...