Although voluntary running has beneficial effects on hippocampal cognitive functions if done abundantly, it is still uncertain whether resistance running would be the same. For this purpose, voluntary resistance wheel running (RWR) with a load is a suitable model, since it allows increased work levels and resultant muscular adaptation in fast-twitch muscle. Here, we examined whether RWR would h...

• Intake of novel food increased over days in mice. Allowing the mice to voluntarily run open wheels suppressed this increase. The suppression was specific paired with voluntary running. This learning occurs without imposed pretraining running closed wheels. Pretraining wheels, however, might facilitates learning. Previous studies (Nakajima, 2019a,b) demonstrated avoidance based on wheel labora...