clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (adp) to its platelet receptor and the subsequent adp-mediated activation of the glycoprotein gpiib/iiia complex, thereby inhibiting platelet aggregation. oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. the aim of this investigation was ...

background: development of biodegradable and biocompatible films based on protein polymer with strong antioxidant and antibacterial activities has gradually obtained extensive concern in the world. in this study, the improvement of gelatin film properties incorporated with ferula assa-foetida essential oil (fao) as a potential antioxidant/antibacterial wound dressing film was investigated. mate...

background and objectives: kefiran (kef) is a water-soluble polysaccharide that can form transparent film however, it is brittle. therefore, in order to improve the mechanical properties of kefiran film, a mixture with other polymers can be offered. the expansion of mixed systems can propose kefiran and polyvinyl alcohol (pvoh) as a new composite film. materials and methods: solutions of 20 gra...

in the current study, whey protein- pullulan- clay nanocomposite films are prepared by casting method. the effect of nanoclay at three concentrations (1%, 3% and 5%) on physical properties such as moisture content, solubility in water, water vapor permeability and transparency of whey protein- pullulan composite films investigated. the results show that the effect of nanoparticles on composite ...

Using the evaporating method, the solubility of potassium Nitrate was determined in various mixtures containing Water and Ethanol at 25°C. The results show that the solubility of KNo3 decreases with increasing the mass percent of Ethanol in the mixtures. This trend is along with decreasing the dielectric constant of Water+Ethanol mixtures. Moreover, it can be concluded that the totqal solubilit...

varying degrees of water solubility. Some additives (e.g., methyl tertiary-butyl ether and alcohols) are highly soluble. Other components (e.g., benzene, toluene, ethylbenzene, and xylenes) are slightly soluble. Many components (e.g., ndodecane and n-heptane) have relatively low water solubility under ideal conditions. Physical and chemical properties which affect transport and fate of selected...

The water solubility of salts is ordinarily dictated by lattice energy and ion solvation. However, in the case of low melting salts also known as ionic liquids, lattice energy is immaterial and differences in hydrophobicity largely account for differences in their water solubility. In this contribution, the activity coefficients of ionic liquids in water are split into cation and anion contribu...

varying degrees of water solubility. Some additives (e.g., methyl tertiary-butyl ether and alcohols) are highly soluble. Other components (e.g., benzene, toluene, ethylbenzene, and xylenes) are slightly soluble. Many components (e.g., ndodecane and n-heptane) have relatively low water solubility under ideal conditions. Physical and chemical properties which affect transport and fate of selected...

Solubility enhancement of meloxicam and rofecoxib, which are poorly soluble in water, was attempted. These are available in the form of solid dosage forms but not in solution dosage forms due to their low aqueous solubility. In this work, aqueous solubility of meloxicam and rofecoxib was improved using the biocompatible solvents such as ethanol, propylene glycol, glycerin, and PEG 400. Physico-...

tant molecular property, playing a large role in the behavior of compounds in many areas of interest. Given the importance of solubility, a means of prediction based solely on molecular structure should prove a useful tool, as many compounds exist for which the solubility simply is not available. The solubility of chemicals and drugs in the water phase has an essential influence on the extent o...