The homeostatic regulation of food intake in fish has been thoroughly studied the last years with dietary nutrient composition is one factors involved. Despite several studies addressed impact insect meal-based diets fish, there no knowledge about their mechanisms regulation. This study aimed to explore underlying through evaluation fishmeal (FM) replacement by defatted (d-) Tenebrio molitor (d...

When food is plentiful, circadian rhythms of animals are powerfully entrained by the light-dark cycle. However, if animals have access to food only during their normal sleep cycle, they will shift most of their circadian rhythms to match the food availability. We studied the basis for entrainment of circadian rhythms by food and light in mice with targeted disruption of the clock gene Bmal1, wh...

BackgroundSodium-glucose cotransporter 2 (SGLT-2) inhibitors are currently used to treat patients with diabetes. Previous studies have demonstrated that treatment SGLT-2 is accompanied by altered metabolic phenotypes. However, it has not been investigated whether the hypothalamic circuit participates in development of compensatory phenotypes triggered inhibitors. MethodsMice were fed a standard...

OBJECTIVE Several hormones expressed in white adipose tissue influence food intake at the central level. We sought to determine whether resistin, a circulating adipose-derived hormone in rodents, has actions on the hypothalamus by determining the effects of central resistin injection on food intake and on hypothalamic Fos protein expression. DESIGN As resistin expression in adipose tissue is ...

PURPOSE: Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, which is widely distributed throughout the mammalian brain including hypothalamus. Immunohistochemical research have reported GABA-ergic neurons and GABAA-receptors on the neurons of the preoptic area of anterior hypothalamus (PO/AH). The aim of this study was to investigate the influence of GABAAergic substan...

We hypothesized that administration of estradiol benzoate to males and testosterone propionate to female neonatal rat pups alters sex-specific ventilatory responses to aspartic acid with correspondent changes in N-methyl-D-aspartate receptor subunit 1 (NR1) expression determined by Western blot in specific brain regions. One-day-old rat pups received estradiol benzoate, testosterone propionate,...

The accumulation of gold in the hypothalamus and the development of hyperphagia and obesity were studied in mice given a single intravenous injection of goldthioglucose at various levels of blood glucose concentration. It was found that the glucose concentration prevailing at the time of goldthioglucose injection was correlated directly with the level of free and bound goldthioglucose in the bl...