A 60-year-old man, a heavy smoker, was hospitalised because of a three-month history of pleuritic chest pain, dry cough and weight loss. He had lost 20 kg in weight and suppurative skin lesions began appearing on the chest wall. His medical history was unremarkable. On examination he was cachectic (44 kg) and pale. His temperature was 37.8°C. Important physical findings of the chest and neck ar...

BACKGROUND Actual body weight (ABW) is important for accurate drug dosing in emergency settings. Oftentimes, patients are unable to stand to be weighed accurately or clearly state their most recent weight. OBJECTIVE Develop a bedside method to estimate ABW using simple anthropometric measurements. METHODS Prospective, blinded, cross-sectional convenience sampling of adult Emergency Departme...

MicroRNAs (miRNAs) play an important role in the development and progression of non-small cell lung cancer (NSCLC). Recently, several studies have shown that miR-539 is down regulated in various cancers, however, its expression and function in NSCLC remain unclear. In this study, we found that miR-539 was downregulated in NSCLC tissues and cell lines. Overexpression of miR-539 suppressed cell p...

The antitumor and antioxidative activities of a rapeseed protein hydrolysate (RSCH) obtained from rapeseed meal were evaluated by using an in vivo S180 tumor-bearing Kunming mice model. Tumor-bearing female mice were given RSCH for 10 at doses of 0, 50, 100, and 150 mg/kg/d by gastric perfusion. RSCH significantly decreased the tumor weight by 44% and 53% in the 100 and 150 mg/kg/d groups, resp...

OBJECTIVE Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants. RESEARCH DESIGN AND METHODS For this study, we analyzed one arm ...

BACKGROUND Data concerning laparoscopic sleeve gastrectomy (LSG) in mild obesity are under investigation. AIM/OBJECTIVE May 2010 to May 2012, 122 consecutive patients with preoperative body mass index (BMI) of 33 ± 2.5 kg/m² (range 30-34.9) undergoing LSG were studied. Mean age was 33 ± 10 years (range 15-60), and 105 (86%) were women. Mean preoperative weight was 91 ± 9.7 kg (range 66-121), ...

Abstract Previous studies have suggested that arsenic crosses the placenta and affects fetus development. The study under consideration aims to show comparative ameliorative effect of Moringa oleifera leaf flower extracts against sodium arsenate induced toxicity mice. Pregnant mice (N=44) were kept in lab divided into eleven group from (A K) orally administered doses 6 mg/kg, 12 mg/kg for arsen...

Presently surgery is the most effective way to obtain a controlled weight reduction in morbidly obese patients. Roux-en-Y gastric bypass (RYGBP) surgery is effective and used worldwide, but the exact mechanism of action is unknown. The effect of RYGBP on ghrelin, insulin, adiponectin, and leptin levels was investigated in 66 obese subjects; mean weight 127 kg (range, 96-195 kg) and mean body ma...

Increasing evidence indicates that the dysregulation of miRNAs that act as tumor suppressors or oncogenes is involved in tumorigenesis. However, the role of miR-539 in hepatocellular carcinoma (HCC) has not been well investigated. Quantitative RT-PCR (qRT-PCR), proliferation assay, colony formation assay, migration and invasion assays, western blotting, and xenograft tumor growth models were pe...