Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the i...

We performed a case-control study to investigate whether SNPs of CHIP might affect the development of IA in Chinese Han nationality. We believe we are the first to have screened IA patients for mutations in the CHIP gene to determine the association with these variants. The study group comprised 224 Chinese Han nationality patients with at least one intracranial aneurysm and 238 unrelated healt...

insulin-like growth factor-i (igf-1) is a peptide hormone which is similar in molecular structure to insulin and it is located on chromosome 5 in cattle. since the igf-1 plays an important role in the growth and development of multiple tissues, the purpose of current study was to identify the igf-1 gene polymorphism in sistani beef cattle. a total of 53 sistani beef cattle (one year) were rando...

Polymorphism of the second exon of the caprine leukocyte antigen-DRB3 gene (CLA-DRB3*02) was investigated in this study. The 285 bp PCR product of 258 individuals from 10 domestic goat breeds in Southwest China was digested with restriction endonucleases PstI and HaeIII and then genotyped. Three alleles and 4 restriction digestion profiles were distinguished by digestion of the PCR fragment by ...

Aims: The planning of this study was to explore the correlation between ataxia-telangiectasia mutated (ATM) gene rs373759, rs664143 polymorphisms and the occurrence risk of coronary artery disease (CAD). Methods: 98 patients with CAD and 109 healthy volunteers who were matched with the former by age and gender, were enrolled in this study. The single nucleotide polymorphisms (SNPs) of ATM were ...

We examined the properties of growth mixture modeling in finding longitudinal quantitative trait loci in a genome-wide association study. Two software packages are commonly used in these analyses: Mplus and the SAS TRAJ procedure. We analyzed the 200 replicates of the simulated data with these programs using three tests: the likelihood-ratio test statistic, a direct test of genetic model coeffi...

population of vimba vimba persa was investigated using microsatellite markers originated from two regions along the iranian coastline of southern caspian sea (anzali lagoon and havigh river in gilan province). totally 153 alleles were identified. the highest number of alleles per ca3 loci was 17 and the lowest 3 in z8145 loci with means of 7.6. observed and expected heterozygosity averages were...