In 1885, Pelizaeus described 5 boys in a single family with nystagmus, spastic quadriparesis, ataxia, and delay in cognitive development. In 1910, Merzbacher reexamined this family, which then included 14 affected individuals, including 2 girls, and found that all affected family members shared a common female ancestor. Also, he noted that the disease was passed exclusively through the female l...

and Implications The prolactin receptor gene was investigated as a candidate gene for reproduction traits in five PIC lines consisting of Large White (2), Landrace, Duroc, and Large White/Meishan origin. Least squares means for total number born (TNB) and number born alive (NBA) were calculated for each genotype in addition to an analysis of additive and dominance effects by line. The PRLR gene...

This prospective study tests the hypotheses that: 1) glaucoma is associated with evidence of cerebral small vessel disease; 2) that imaging biomarkers of cerebral small vessel disease in POAG and NTG will show different characteristics. 12 normal controls, 7 patients with primary open angle glaucoma (POAG) and 9 patients with normal tension glaucoma (NTG) were recruited. Ophthalmological clinic...

With interest we have read the article by White et al. 1 In their well-designed prospective cohort study, they demonstrate the importance of increased 24-hour systolic blood pressure, but not clinic systolic blood pressure, in the progression of brain white matter hyperintensity volume burden associated with impairment of cogni-tive function in older people. They conclude that 24-hour of systol...

Methods: Three concentrations of carbamide peroxide (10%, 16%, and 22%) used in home bleaching techniques were evaluated regarding their cytotoxic effect on gingival tissues. The materials were divided into three groups as follows: Group C10 (White Gold Home 10%, Dentsply), Group C16 (White Gold Home 16%, Dentsply, and Group C22 (Nite White 22%, ACP Discus Dental). The cytotoxicity essay was ca...

Focal epithelial hyperplasia or Heck’s disease is a benign, rare viral disease of the oral cavity and is associated with human papillomavirus 13 and 32 (HPV-13 and HPV-32). Most patients are children but adults may also be at risk. Clinically, the patients have multiple small white or pink papules on the mucosal surface of the lips, buccal mucosa and the tongue. In Iran, this disease seems to b...

this study was carried out in the winter of the year 2007 in a dairy herd at the vicinity of tehran (eslamshahr). measurements were performed on 18 holstein cows during first-lactation. five holstein dairy cattle were randomly selected and clinically studied, too. length of the claw’s dorsal flexure was measured with a ruler and also the hooves trimmed in the toe vertically for measuring of the...

Abstract Background In Alzheimer’s disease, cognitive decline is associated with a rapid increase in tau pathology, making tau‐PET potentially useful outcome prevention trials. To identify individuals most at‐risk of accumulation, we investigated the longitudinal associations between amyloid and clinically normal (CN) impaired (MCI/AD) participants from Harvard Aging Brain Study. Method Serial ...