In the nearly 50 years since the description of Williams syndrome by [Williams et al. (1961); Circulation 24:1311-1318], the focus of scientific inquiry has shifted from identification, definition, and description of the syndrome in small series to genotype-phenotype correlation, pathophysiologic investigation in both humans and in animal models, and therapeutic outcomes in large cohorts. Study...

1 From the Imaging Division, Lawson Health Research Institute, London, Ontario, Canada (L.A.W., N.G., P.A.P., D.S.L., V.K.H., R.T.T.); Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada (L.A.W., N.G., P.A.P., R.T.T.); Departments of Nuclear Medicine (L.A.W.), Radiology (N.G., R.T.T.), and Maternal and Newborn Health (D.S.L., V.K.H.), St Joseph’s Health Care...

I R. J. Williams, Quart. J. Studies Alc., 7, 567, 1947. 2 R. J. Williams, Biochemical Individuality (New York: John Wiley & Sons, 1956). 3R. J. Williams, E. Beerstecher, Jr., and L. J. Berry, Lancet, 1, 287, 1950. 4R. J. Williams, Nutrition and Alcoholism (Norman, Okla.: University of Oklahoma Press. 1951). 5E. Beerstecher, Jr., H. E. Sutton, H. K. Berry, W. D. Brown, J. Reed, G. B. Rich, L. J....

was also made for n-propyl isocyanide, which was suspected, because of its color, to be contaminated with a small amount of n-propyl iodide. The values of the equilibrium constants were averaged, with the concentration of free isocyanide as a weight factor. The equilibrium constants obtained in this way are 2.0 X 105 for ethyl isocyanide, 1.1 X 105 for n-propyl isocyanide, 1.4 X 104 for isoprop...

rospectively. However, for years, retrospective reports of pregnancy wantedness have been recognized to be subject to recall error or rationalization. As long as three decades ago, it was noted that respondents might not admit to what could be perceived as an inadequacy, or that they might change their attitude based on positive experiences with a child resulting from a pregnancy that, at conce...