The present study was performed to examine the relation between the gain of the baroreceptor reflex and the pathogenesis of hypertension in the spontaneously hypertensive rat. Spontaneously hypertensive or Wistar-Kyoto rats underwent either sinoaortic baroreceptor denervation or sham denervation at 28-35 days of age. Four months later these rats were chronically instrumented for measurements of...

The hedonic component of the feeding behavior involves the mesolimbic reward system and resembles addictions. Nowadays, the excessive consumption of sucrose is considered addictive. The Wistar-Kyoto (WKY) rat strain is prone to develop anxiety and addiction-like behavior; nevertheless, a lack of information regarding their vulnerability to develop sugar binging-like behavior (SBLB) and how it a...

The effects of age and blood pressure on fibronectin expression in the rat heart were studied in the normotensive Wistar and Wistar-Kyoto (WKY) strains and in the spontaneously hypertensive rat (SHR). Fibronectin mRNA expression decreased threefold between 10 and 40 weeks of age in Wistar hearts, with changes of similar magnitude occurring between 6 and 24 weeks in WKY rats. In contrast, no dec...

The development of vitamin K deficiency, vitamin K requirement and warfarin susceptibility were studied in several types of warfarin-resistant .and non-resistant rat. Domesticated HW strain rats needed about 13 times as much vitamin Kl as did Wistar rats to maintain normal blood-clotting function, while HS strain rats were intermediate in this and in their susceptibility to warfarin. The vitami...

AIM The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. MATERIALS AND METHODS This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats. The dead rats were subjected to thorough post-mortem examination and necropsy samples were processed for hematoxylin and eosin staining for histopatholog...

OBJECTIVE Streptozotocin (STZ)-induced diabetes in Wistar rats results in severe hyperlipidemia and a characteristic cardiomyopathy. However, Wistar-Kyoto (WKY) rats made diabetic with a similar dose of STZ did not develop heart dysfunction or hypertriglyceridemia at 12 weeks post-STZ. We investigated whether an apparent resistance of the WKY strain to develop diabetic cardiomyopathy and hypert...

Cellular dimensions in mesenteric resistance vessels from 10 spontaneously hypertensive rats and 10 Wistar-Kyoto rats have been determined using a random volume with an unbiased counting rule as the counting unit (the disector). With this method, vessels first were mounted on a myograph. Media thickness (spontaneously hypertensive rats, 11.3 micron; Wistar-Kyoto rats, 8.6 micron; P less than 0....

The low incidence of cardiovascular diseases, including hypertension, in premenopausal women has led to the conclusion that ovarian hormones may have a protective effect on the cardiovascular system. We evaluated the effects of ovariectomy and/or estradiol on sympathovagal balance and heart rate variability (HRV) in female spontaneously hypertensive rats (SHR) with tachycardia and compared them...

The small intestine is the largest component of the digestive tract and the major site of digestion and absorption. Aluminium compounds are used in pharmaceuticals and in water treatment processes. The purpose of this experiment was to evaluate the possible effects that aluminium chloride exposure could have on the histology of the small intestine of wistar rats. The wistar rats were divided in...

21 Spontaneous hypertensive rats (SHR) are widely used as a model of attention deficit 22 hyperactivity disorder (ADHD) as their ADHD-like behaviors are restored by 23 methylphenidate (MPH). However, a postnatal neural development in SHR is unknown. 24 We performed whole cell patch clamp recordings from locus coeruleus (LC) neurons in 25 neonatal (P 3–5), juvenile (P 21–28) and adult (P 49–56) ...