objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

Amaç: Ratlarda, deneysel monooküler deprivasyon ambliyopisi modelinde rolipramın, vizüel kortikal plastisite üzerindeki etkisinin elektrofizyolojik ve elektron mikroskobik olarak incelenmesidir. Gereç Yöntemler: Yirmi dört Wistar albino cinsi rat, her grupta 4 rat olacak şekilde rastgele 6 gruba ayrıldı. Kontrol grubu dışındaki ratlar dışında tüm ratların sağ göz kapakları 21-45. günleri arası ...

Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these compounds, catalyzed by UDP-glucuronosyltransferases (UGTs), is well known to be a primary step in their metabolism to hydrophilic products and in their ultimate excretion. The present study was design...

We hypothesize that the inner medulla of the kangaroo rat Dipodomys merriami, a desert rodent that concentrates its urine to more than 6,000 mosmol/kgH(2)O water, provides unique examples of architectural features necessary for production of highly concentrated urine. To investigate this architecture, inner medullary nephron segments in the initial 3,000 μm below the outer medulla were assessed...

A nonpathogenic strain of rat virus, L-S strain, was isolated from a Wistar rat bearing chloroleukemia. Five other chloroleukemic rats and 21 other tumor-bearing rats yielded no virus. The L-S virus grows on embryonic rat but not embryonic mouse tissue and produces a cytopathogenic effect (CPE) which is slightly different from that produced by Kilham's latent rat virus (RV). Data are presented ...

Circulating and tumor-based biomarkers predict clinical activity in cancer patients treated with the engineered anti-PD-L1 antibody MPDL3280A Marcin Kowanetz, Christina Rabe, Yuanyuan Xiao, Qun J Wu, Hartmut Koeppen, Cecilia Leddy, Rajesh D Patel, John Powderly, Holbrook Kohrt, Scott Gettinger, Jean-Charles Soria, Roy S Herbst, Rupal Desai, Mitchell Denker, Jane Ruppel, Marigold Boe, Rin Nakamu...

The Goto-Kakisaki (GK) rat is a genetic model of type 2 diabetes obtained by selective inbreeding of mildly glucose-intolerant Wistar rats. Previous studies have shown that at birth, the -cell mass of the GK rat is severely reduced compared with that of the Wistar rat. Therefore, -cell deficit could be the primary defect leading to type 2 diabetes in this model. To identify the abnormality at t...

Rat oocytes can be produced artificially by superovulation. Because some strains show low sensitivity to superovulation treatment, in vitro maturation is an alternative method to produce numerous matured oocytes. Furthermore, establishment of an in vitro maturation system with simple culture conditions is cost effective and leads to easy handling of oocytes. This study examined developmental ab...