A functionalized derivative of the alpha 2-selective antagonist rauwolscine formed the basis for a photoaffinity adduct that has allowed identification of the hormone-binding subunit of the brain alpha 2-adrenergic receptor protein. Rauwolscine carboxylate underwent reaction with 4-N-t-butyloxycarbonyl-aminoaniline, leading to the synthesis of rauwolscine 4-aminophenyl carboxamide (Rau-AmPC). R...

BACKGROUND Research in 2007 showed that World Health Organization (WHO) recommendations were largely based on expert opinion, rarely used systematic evidence-based methods, and did not follow the organization's own "Guidelines for Guidelines". In response, the WHO established a "Guidelines Review Committee" (GRC) to implement and oversee internationally recognized standards. We examined the imp...

.. There are a number of growth references available for children internationally but in 2006 the World health organization published growth standards for children 0 60 months. These growth standards have been adopted even by the developed countries though with some modifications. This article discusses the various aspects of growth standards including plotting of charts and their interpretation.

The Revised European-American Classification of Lymphoid Neoplasms (REAL) classification has been validated by a multi-institutional study, and project data showed that it is both reproducible and clinically relevant. The new World Health Organization (WHO) Classification of Neoplastic Diseases of Hematopoietic and Lymphoid Tissues, as a joint project of the Society of Hematopathology and Europ...

Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-...

CMAJ • APR. 29, 2003; 168 (9) 1169 Epidemiologist Jong Wook Lee, a South Korean expert on vaccines, tuberculosis and poverty-related disease, is expected to succeed Dr. Gro Harlem Brundtland as director general of the World Health Organization (WHO) in July. His nomination by the 32-member WHO Executive Board will likely be rubber-stamped by the World Health Assembly in May. The very political ...