What I intended for this part was simply inspection of pairwise scatterplots and correlation coefficients. (Three-dimensional exploration — 3-D plots, or 2-D scatterplots with panels for different ranges of a third variable — might also be useful, but was more than I expected and in any event my limited exploration of these didn’t reveal anything noteworthy.) Because many of the variables have ...

Often considered no more than an historical curiosity, writer's cramp remains an important disability in the workplace and the mechanism, which has puzzled the best medical minds for generations, remains contentious. A remarkable range of hypotheses has been put forward to try and explain a disability which periodically reached epidemic and economically worrying levels, but in the end medical o...

Motor imagery (MI) is the mental rehearsal of a motor act without overt movement. Using transcranial magnetic stimulation (TMS), we tested the effect of MI on corticospinal excitability in patients with writer's cramp. In 10 patients with writer's cramp and 10 healthy controls, we applied focal TMS over each primary motor area and recorded motor evoked potentials (MEPs) from contralateral hand ...

Paneth cell-derived enteric antimicrobial peptides provide protection from intestinal infection and maintenance of enteric homeostasis. Paneth cells, however, evolve only after the neonatal period, and the antimicrobial mechanisms that protect the newborn intestine are ill defined. Using quantitative reverse transcription-polymerase chain reaction, immunohistology, reverse-phase high-performanc...

Focal hand dystonia is a disorder in which sensory and motor anomalies emerge that appear to be grounded in maladaptive routes of cortical plasticity. Remodeling cortical networks through sensory-motor retuning (SMR), we achieved long-term reduction in the symptoms of focal hand dystonia. Magnetoencephalography confirmed that SMR modified the representational cortex of the fingers, whereby the ...

LL-37, an active form of human cathelicidin exhibits various effects on immunity and inflammation, such as induction inflammatory cells angiogenesis in addition to its antimicrobial activity. Involvement LL-37 the pathogenesis several skin diseases psoriasis rosacea has been described. To search for association other diseases, we focused scleroderma dermatomyositis. Previously, it shown that is...