Objective: The present study was aimed to find out the central and peripheral analgesic activity of aqueous leaf extract of Solanum melongena Linn (AESML) in experimental animals. Methods: Preliminary phytochemical analysis of AESML was performed by chemical tests. The central analgesic activity was measured by tail flick method in Wistar rats and peripheral analgesic activity was measured by a...

Calendula Of.cinalis (Asteraceae) is widely used in traditional medicine as an anti-in.ammatory agent and has also been reported to have anti-bacterial, anti-fungal and anti-viral activities.  Sesquiterpene glycosides, saponins, triol, triterpenes and .avonoids are observed in its composition. The present study was designed to evaluate the antinociceptive effect of hydro-alcoholic extract of Ca...

Aims of the present study were to investigate effects of Balanophora spicata (BS) on antinociception and anti-inflammation both in vivo and in vitro. Crude extract of BS inhibited vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2), but not by PAF. Furthermore, BS crude extract, different layers (n-hexane, ethyl acetate, n-butanol, and water layer), and lupeol acetate ...

BACKGROUND Ocimum suave willd is one of the plants traditionally used for the treatment of inflammation and related disorders in different parts of Ethiopia. The aim of the current study was to evaluate the analgesic and antipyretic activities of the solvent fractions (n-butanol and water) of O. suave aqueous leaves extract. MATERIALS AND METHODS Acetic acid writhing and tail flick tests were...

Latar belakang: Asam asetilsalisilat merupakan obat analgesik yang masih popular digunakan. Namun asam dapat menimbulkan efek samping tukak lambung hingga pendarahan. Penelitian terdahulu telah berhasil mensintesis senyawa baru turunan salisilat yaitu 4-(klorometil)salisilat memberikan lebih ringan dengan farmakologis baik dibandingkan asetilsalisilat. Dalam perkembangannya dilakukan pula formu...

Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen ...

OBJECTIVE The present study was carried out to investigate the possible in vivo analgesic, neuropharmacological and anti-diarrheal activities of the methanol extract of Jatropha gossypifolia fruits. MATERIALS AND METHODS The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuropharmacological activities were evaluated by hole cross, hole-board, and elevate...

Antinociceptive activity of methanolic extract of leaves of A. aspera was studied by peripheral/non-narcotic model of nociception like acetic acid induced writhing syndrome test and central/narcotic models like hot plate and tail flick tests. The methanolic extract of the plant, administered orally (@ 300, 600 and 900 mg/kg, body weight) and the standard drug (piroxicam; 10 mg/kg body weight, p...

objective: the present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of solanum sisymbriifolium lam. (family: solanaceae). materials and methods: the analgesic activity was measured by acetic acid-induced writhing inhibition test. the neuropharmacological activities were evaluated using ho...

The extract of the bark of Albizia lebbeck Benth. obtained by cold extraction of mixture of equal proportions of petroleum ether, ethyl acetate and methanol was chosen for pharmacological screening. In rat paw edema model induced by carrageenan, the extract at the 400 mg/kg dose level showed 36.68% (p<0.001) inhibition of edema volume at the end of 4h. In the acetic acid-induced writhing test, ...