This multicenter, observational drug utilization (DU) study (NCT01594996) investigated the profile of patients and specialist providers who prescribed extended release quetiapine fumarate (quetiapine XR) for treatment of major depressive disorder (MDD) across five European countries (Germany, Italy, Romania, Spain, and Sweden). A DU data abstraction form captured information on the characterist...

Let XR be a (generalized) flag manifold of a non-compact real semisimple Lie group GR, where XR and GR have complexifications X and G. We investigate the problem of constructing a graded star product on Pol(T ∗XR) which corresponds to a GR-equivariant quantization of symbols into smooth differential operators acting on half-densities on XR. We show that any solution is algebraic in that it rest...

A transitive subgroup G ≤ SN is called a genus zero group if there exist non identity elements x1 , . xr∈G satisfying =<x1, xr>, x1·...·xr=1 and ind x1+...+ind xr = 2N − 2. The Hurwitz space Hinr(G) the of coverings Riemann sphere P1 with r branch points monodromy G.In this paper, we assume that finite PSp(4, q) Aut(PSp(4, q)) acts on projective 3-dimensional geometry PG(3, q), q prime po...

The enzymatic bioconversion of xylose into xylitol by xylose reductase (XR) is an alternative for chemical and microbiological processes. The partial purified XR was obtained by using the following three procedures: an agarose column, a membrane reactor or an Amicon Ultra-15 50K Centrifugal Filter device at yields of 40%, 7% and 67%, respectively.

This article presents a summary of available data on the use of quetiapine extended release (QUE-XR). QUE-XR is an example of an atypical antipsychotic drug that can be used in a single dose, thereby simplifying the treatment regimen. From the therapeutic standpoint, this issue is of paramount importance, since approximately 50% of patients have adherence issues. Therefore, availability of the ...

This international, randomized, double-blind trial (NCT01864174) compared the efficacy and safety of metformin extended-release (XR) and immediate-release (IR) in patients with type 2 diabetes. After a 4-week placebo lead-in, pharmacotherapy-naïve adults with glycated haemoglobin (HbA1c) at 7.0% to 9.2% were randomized (1:1) to receive once-daily metformin XR 2000 mg or twice-daily metformin IR...

The absorption spectra of the GAFCHROMIC XR type R radiochromic film measured with reflectance spectroscopy have been investigated in order to analyze the dosimetry characteristics of the film. Like the XR type T film, this film features two peaks in its absorption spectrum, approximately at 676 and 618 nm, whose intensities increase with increasing absorbed dose. When the main absorption peak ...

BACKGROUND Overactive bladder (OAB) is often associated with a number of co-morbid medical conditions, including diabetes mellitus. This may necessitate several concomitant treatments, thus creating the potential for drug-drug interactions (DDIs). Trospium is renally eliminated, not metabolized via cytochrome P450; therefore, cytochrome P450 DDIs are unlikely. However, coadministration with ano...

The intersection between music and Extended Reality (XR) has grown significantly over the past twenty years, amounting to an established area of research today. use XR technologies represents a fundamental paradigm shift for various musical contexts as they disrupt traditional notions interaction by enabling performers audiences interact musically with virtual objects, agents, environments. Thi...

Let P be a poset with unique minimal and maximal elements 0̂ and 1̂. For each r, let Cr(P ) be the vector space spanned by r-chains from 0̂ to 1̂ in P . We define the notion of a Hodge structure on P which consists of a local action of Sr+1 on Cr, for each r, such that the boundary map ∂r : Cr → Cr−1 intertwines the actions of Sr+1 and Sr according to a certain condition. We show that if P has a Ho...