PURPOSE New treatments are introduced routinely into clinical practice without rigorous economic analysis. The specific aim of this study was to examine the cost effectiveness of proton beam radiation compared with current state-of-the art therapy in the treatment of patients with prostate cancer. MATERIALS AND METHODS A Markov model was informed with cost, freedom from biochemical failure (F...

INTRODUCTION Men who have sex with men (MSM) are disproportionately affected by HIV due to their increased risk of infection. Oral pre-exposure prophylaxis (PrEP) is a highly effictive HIV-prevention strategy for MSM. Despite evidence of its effectiveness, PrEP uptake in the United States has been slow, in part due to its cost. As jurisdictions and health organizations begin to think about PrEP...

BACKGROUND In oncology, establishing the value of new cancer treatments is challenging. A clear definition of the different perspectives regarding the drivers of innovation in oncology is required to enable new cancer treatments to be properly rewarded for the value they create. The aim of this study was to analyze the views of oncologists, health care policy makers, patients, and the general p...

PRINCIPLES Current evidence indicates that chronic kidney disease (CKD) can be detected by simple laboratory tests. This study aimed to evaluate the cost-effectiveness of microalbuminuria screening and subsequent treatment in different populations. METHODS Cost-effectiveness of microalbuminuria screening in a cohort of simulated subjects aged ≥50 years was assessed using a validated microsimu...

INTRODUCTION Highly active antiretroviral therapy (HAART) has allowed many HIV-infected patients to enjoy longer survival and a better quality of life. We performed an economic analysis to estimate the cost-effectiveness of HAART regimens in Italy for managing HIV-naïve infected patients with a viral load below 100,000 copies/mL. PATIENTS AND METHODS The population considered in the model con...

BACKGROUND The cost-effectiveness of aspirin for primary prevention of cardiovascular events in women is unclear. We sought to perform a cost-utility analysis to address this issue. METHODS We developed a Markov model, based on published literature, to compare aspirin prevention with no therapy. We used the perspective of a third-party payer and a lifetime time horizon. Our main outcome measu...

This study aimed to compare the partitioned survival model (PSM) and two state transition models considering additional health states with heterogeneity. To provide an illustration of impact on results life-year quality-adjusted (QALY), economic for osimertinib pemetrexed-platinum in EGFR-mutated advanced non-small cell lung cancer were developed. Three constructed using parametric curves fitte...

Background Cost-effectiveness analysis is an important tool for informing treatment coverage and pricing decisions, yet no consensus exists about what threshold the incremental cost-effectiveness ratio (ICER) in dollars per quality-adjusted life-year (QALY) gained indicates whether treatments are likely to be cost-effective United States. Objective To estimate a U.S. based on health opportunity...

Pelvic inflammatory Disease (PID) disproportionately impacts adolescent and young adult women with the risk of major reproductive health sequelae. The Technology-Enhanced Community Health Nursing (TECH-N) trial demonstrated potential benefit a novel community nursing intervention for female adolescents PID in an urban setting. In this study, we assess cost-effectiveness such compared to standar...