Lipid nanocapsules (LNCs) represent a stable, biocompatible and worthwhile drug delivery system, demonstrating significant potential as gene/drug delivery platforms for cancer therapy. Imatinib, a potent tyrosine kinase inhibitor, has revolutionized the therapy of malignancies resulting from abnormal tyrosine kinase activity. However, its Clinical effectiveness in cancer treatment is h...

Objective(s): Colorectal cancer (CRC) is a prevalent cancer worldwide. The present study aimed to synthesize and investigate the potential of wheat germ agglutinin (WGA) conjugated with polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) incorporating 5-fluorouracil (5-FU). Materials and Methods: The NPs were investigated in terms of various characteristics, such as the particle size, ...

The electroviscous effect has been widely studied to investigate the effect of surface charge-induced electric double layers (EDL) on the pressure-driven flow in a micro/nano channel. EDL has been reported to reduce the velocity of fluid flow and increase the fluid drag. Nevertheless, the study on the combined effect of EDL with large zeta potential up to several hundred millivolts and surface ...

Simple zwitterions used as auxiliary agents might have the potential to change zeta of oil-in-water (o/w) nanoemulsions on mucosa. The zwitterion phosphorylated tyramine (p-Tyr) was synthesized by phosphorylation Boc-tyramine (Boc-Tyr) using phosphoryl chloride (POCl3). It incorporated with 2% (m/v) in a self-emulsifying lipophilic phase comprising Captex 35, Cremophor EL, Capmul MCM and glycer...

The present work aims to investigate the effect of sulphanilamide (SA) adsorption on the zeta potential and water loss of raw local bentonite (B) and Na-bentonite (Na-B) suspensions. This was accomplished by separating the fine particles of raw bentonite of size (< 1μm), then activating them by Na+ ions. Adsorption isotherms of SA on B and Na-B were obtained at different SA concentrations rangi...

BACKGROUND The cause-effect relationships between physicochemical properties of amphiphilic [60]fullerene derivatives and their toxicity against bacterial cells have not yet been clarified. In this study, we report how the differences in the chemical structure of organic addends in 10 originally synthesized penta-substituted [60]fullerene derivatives modulate their zeta potential and aggregate'...

objective: the objective of this study is to develop and assess targeted pamam-peg nanocarrier with anti-tag72 nanobody for t-bid gene coding construct delivery into the human colonic adenocarcinoma cells. materials and methods: nanobody (nb) coding sequence was subcloned into psj expression vector for large-scale production and then nb was purified by ni++ affinity chromatography. sds-page an...