objective the lennox-gastaut syndrome (lgs: the triad of intractable seizures of various types, a slow spike-wave pattern in eeg and mental retardation) is one of the most difficult epilepsy syndromes to treat. the aim of this study was to evaluate the efficacy and safety of zonisamide (zns) as add-on therapy in seizures of children with lgs. materials & methods in a quasi- experimental study, ...

Objective: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide—reviewed in the order in which these agents received approval by the US Food and Drug Administration) in the treatment of children and adults with newly diagnosed partial and gener...

Objective: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee including general neurologists, pediatric neurologists, ...