the purpose of this study was to prepare and characterize microspheres loaded by cyclosporine a(cya)-cyclodextrin (cd) complex. to achieve this goal, plga microspheres loaded by cya cd complex were prepared by multiple emulsificationsolvent evaporation methods.morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. microscopic evaluation of microspher...

Piroxicam-beta-cyclodextrin is a complex of the established nonsteroidal antiinflammatory drug (NSAID) piroxicam and an inert cyclic macromolecule, beta-cyclodextrin. In clinical trials in patients with rheumatic diseases or pain arising from other conditions, it was as effective an analgesic as standard piroxicam, and showed a faster onset of action on the first day of treatment. In short term...

A series of novel bis(beta-cyclodextrin)s tethered with organoselenium linkers, i.e., 6,6'-(o-phenylene-diseleno)-bridged bis(beta-cyclodextrin) (2), 6,6'-[2,2'-diselenobis(benzoyloxy)]-bridged bis(beta-cyclodextrin) (3), and 6,6'-[2,2'-diselenobis[2-(benzoylamino)ethylamino]]-bridged bis(beta-cyclodextrin) (4), were synthesized from beta-cyclodextrin (1). The inclusion complexation behavior of...

Objective: Several studies have shown that the adult pancreas possesses a limited potential for ß– cell regeneration upon tissue injury. One of the difficulties in studying ß-cell regeneration has been the lack of a robust, synchronized animal model system that would allow controlled regulation of ß−cell loss and subsequent proliferation in adult pancreas. Research Design and Methods: Here we p...

für die resultierende mittlere Geschwindigkeit eines Teilchens nach einem Stoß: t>red = v c p . Aus den Gesetzen des elastischen Stoßes für Kugeln der Massen m0, mx ergibt sich für die Geschwindigkeit von 77i0 nach dem Stoß mit ß = ( (m x m0 ) / (m, + m 0 ) ) 2, e=(l/ß-l) (d/R0)2 : v=v0(ßey*(( 1 + 1/fi) — cos2 ft)1'*; (A.6) cos #m i n = (1 (R0/d)2 (ß (vmJv 0)2)/ (ß-1) cos # m a x = (1 (R0/d)2)1...

Due to the asymmetry introduced by the hypothesis (2), the above theorem leaves open the case where ß >ct. Actually, the entire theorem as it stands holds without hypothesis (3). This results from the fact that Erdös' proof of the theorem given in [l ] uses only the condition a>ß/2. In the contrary case, 2a=/3, if we let ai be any fixed integer of A, the set {ö+cti}, b^B, has asymptotic density...

BACKGROUND ß-Adrenergic receptor antagonists (beta-blockers) are frequently used with the aim of reducing perioperative myocardial ischemia and infarction. However, randomized clinical trials specifically designed to evaluate the effects of beta-blockers on mortality in patients undergoing non-cardiac surgery have yielded conflicting results. OBJECTIVE This study aimed to examine the effect o...

The theorem about primitive divisors in algebraic number fields is generalized in the following manner. Let A, B be algebraic integers, (A, B) = 1 , AB ^ 0, A/B not a root of unity, and Çk a primitive root of unity of order k . For all sufficiently large n , the number A" C,kB" has a prime ideal factor that does not divide Am £,'kBm for arbitrary m < n and j < k . The analogue of Zsigmondy's th...

Segmental mandibulectomy leads to a great deÞ cit in the form and function of the patient. Vascularised bone ß aps have become the choice of the method of reconstruction of the mandible in an oncologic setting. Fibula osseous or oseteocutaneous ß aps have become the favored method in centers across the world. This article reviews certain pertinent and practical points with regards to Þ bula ß a...

ß-Lactams are the most widely used antibiotics, and ß-lactamases are the greatest source of resistance to them. Colorimetric tests are good, rapid, indicators of ß-lactamase production and its contingent resistance in Haemophilus, Moraxella and Neisseria spp. They can also be applied to Gram-negative bacilli but are less useful, since the usual question is not whether a ß-lactamase is produced ...