Background: Pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (free β-hCG) as valuable biochemical biomarkers are used to screen down syndrome, Edwards syndrome, and Patau syndrome in the first trimester of pregnancy. Closed immunoassay analyzers are regarded as sophisticated platforms to measure biochemical biomarkers. This study compared the performance of...

Amaç: Plasenta previa (PP) tanılı olgularda plasenta akreta indeks (PAI) skoru ile ilk trimester serum belirteçlerinin (PAPP-A, serbest β HCG) Akreta Spektrumu (PAS) öngörüsündeki yerini araştırmayı amaçladık.
 Gereç ve Yöntemler: Çalışmamıza 30 PAS, adezyon anomalisi saptanmayan olgusu 60 sağlıklı gebe dahil edildi. Çalışmaya edilen olguların, üçüncü trimesterda PAI belirlendi, ardından b...

Objective: To determine medians of pregnancy-associated plasma protein-A (PAPP-A) and free β subunit Human Chorionic Gonadotropin (hCG-β) in the first trimester healthy pregnant women visiting tertiary care hospital.
 Study Design: Cross-sectional study.
 Place Duration Study: Department Chemical Pathology Endocrinology, Armed Forces Institute (AFIP) from May 2018 to 2019.
 Metho...

A Krukenberg tumor is a rare and potentially deadly cause of elevated serum β-hCG as part of a paraneoplastic syndrome. This study aims to describe the unusual case of a 36-year-old woman that presented to the Emergency Department (ED) with back pain and a positive urine pregnancy test. Assessment revealed no intrauterine pregnancy and a small left ovarian cyst. Further investigation showed mod...

BACKGROUND First-trimester prenatal screening for aneuploidy by use of dried blood spots (DBSs) may offer practical benefits in settings where the instability of intact human chorionic gonadotropin (hCG) is problematic. We evaluated a DBS pregnancy-associated plasma protein A (PAPP-A) and free β-subunit of hCG (free hCGβ) dual assay and compared it to serum screening. METHODS Hematocrit-corre...

Many findings point to the presence of a close relationship between the immune, endocrine and neurologic systems. For example the suppressive effects of β-human chorionic gonadotropin (β-HCG) on IL-l production, the potentiative effect of enkephalins on lymphocyte functions and the suppressive effect of leuteinizing hormone (LH) on natural killer (NK) cell activities have been clearly esta...

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 occurrence of miscarriage in first trimester, cases with history recurrent loss. Methods: Serum levels fifty pregnant women loss were compared to 50 no abortion, another group (No=50) who failed complete 1st trimester during study. Results: B-hCG showed a sensitivity 100%, specificity 50%...

We describe a 26-year-old man with metastatic choriocarcinoma who presented with hyperthyroidism associated with elevated β-human chorionic gonadotropin (B-HCG) and respiratory failure secondary to diffuse lung metastasis. After the first cycle of chemotherapy, the concentration of B-HCG dramatically decreased and the patient became euthyroid, allowing us to discontinue antithyroid medications....

Members of the transforming growth factor-β (TGF-β) superfamily are likely to have major roles in the regulation of tissue and vascular remodelling in the corpus luteum (CL). There are four inhibitor-of-differentiation (ID1-4) genes that are regulated by members of the TGF-β superfamily and are involved in the transcriptional regulation of cell growth and differentiation. We studied their expre...

OBJECTIVE It was the aim of this study to examine the possible effects of maternal and fetal characteristics on the fetal fraction in maternal plasma cell-free DNA (cfDNA) at 11-13 weeks' gestation. METHODS In a nested case-control study, cfDNA was extracted from maternal plasma obtained before chorionic villous sampling from 300 euploid, 50 trisomy 21 and 50 trisomy 18 pregnancies at 11-13 w...