INTRODUCTION The risk of drug resistance and the use of medicinal plants in malaria prevention and treatment have led to the search for new antimalarial compounds with natural origin. METHODS In the current study, six extracts with different polarity from aerial parts and rhizomes of Eremostachys macrophylla Montbr. & Auch., were screened for their antimalarial properties by cell-free β-hemat...

A new molecule of 2-[3, 4 di hydroxy phenyl] 3, 5, 14-trihydroxy 13oxo 2H-chromeno [34:5, 6] pyrano [2, 3-h] 4H-chromene 4-one was synthesized and screened. This new compound was synthesized by incorporating 4-chloro-3-formyl coumarin group with quercetin compound. In the present study the antioxidant and antimalarial activities of new 2-[3, 4 di hydroxy phenyl] 3, 5, 14-trihydroxy 13oxo 2H-chr...

background: the canonical wnt signal transduction (or the wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. beta-catenin is the central component of this signaling pathway. the activation of wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. in the nucleus, β-catenin interacts with the tcf/lef transcription fa...

synthesis of some new monocyclic β-lactams containing a quaternary carbon center via a [2+2]cycloaddition reaction is described. the reaction of achiral diphenyl ketene with chiral aldimines derivedfrom chiral 2, 3, 4, 6-tetra-o-acetyl-β-d-galactopyranosylamine, 2, 3, 4, 6-tetra-o-acetyl-β-dglucopyranosylamine and different benzaldehydes resulted in the formation of β-lactams as singlediastereo...

Johnston, M. A. (Cornell University, Ithaca, N.Y.), and E. A. Delwiche. Distribution and characteristics of the catalases of Lactobacillaceae. J. Bacteriol. 90:347-351. 1965.-Certain strains of lactobacilli and pediococci incorporated hematin during growth, with the concomitant formation of cyanide- and azide-sensitive catalase. Three of five strains of lactobacilli and five of 25 strains of pe...

The human malaria parasite Plasmodium falciparum detoxifies the heme byproduct of hemoglobin digestion in infected red blood cells by sequestration into submicron-sized hemozoin crystals. The crystal is composed of heme units interlinked to form cyclic dimers via reciprocal Fe─O (propionate) bonds. Templated hemozoin nucleation was envisaged to explain a classic observation by electron microsco...

Oxygenation of the 5-lipoxygenase product 5S-hydroxyeicosatetraenoic acid by cyclooxygenase-2 yields a bicyclic di-endoperoxide. The di-endoperoxide contains two peroxides spanning from carbons 9 to 11 and 8 to 12, and two hydroxyls at carbons 5 and 15 of arachidonic acid (Schneider C., et al. 2006. Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2. J. Am. Chem. ...

Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway. The activation of Wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. In the nucleus, β-catenin interacts with the TCF/LEF transcription fa...