Interleukin 12 (IL-12) and/or interleukin 18 (IL-18) gene ablated mice were applied for the investigation of the tissue expression of interferon γ (IFN-γ). For IL-12, IL-18, IL-12/18 and wt mice, reproductive performance were recorded and IFN-γ concentrations in heart, lung, liver, spleen, kidney and serum were quantified by ELISA. There were no significant differences of IFN-γ in heart, lung a...

Background: Vitamin D plays a key role in the modulation of numerous immune functions against infectious agents. We aimed to explore association between serum 25‑hydroxyvitamin (25[OH] D) levels and cytokine responses, along with hematological changes, patients urinary tract infection (UTI). Materials Methods: level, cytokines (interferon [IFN]−γ, interleukin [IL]−4, IL−6, IL–10, IL−17A, tumor ...

Many reports have demonstrated that Mycoplasma pneumonia (M. pneumoniae) infection may cause the release of multiple cytokines into sputum or serum samples. However, studies focusing on bronchoalveolar lavage fluid (BALF) samples are scarce. The aim of this study was to identify the cytokines associated with M. pneumoniae infection, and explore the possible factors affecting their secretion dur...

We report here an unliganded receptor structure in the common gamma-chain (γ(c)) family of receptors and cytokines. The crystal structure of the unliganded form of the interleukin-7 alpha receptor (IL-7Rα) extracellular domain (ECD) at 2.15 Å resolution reveals a homodimer forming an "X" geometry looking down onto the cell surface with the C termini of the two chains separated by 110 Å and the ...

BACKGROUND Interferon-γ (IFN-γ) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-γ. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value. METHODS Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-γ...

mendelian susceptibility to mycobacterial diseases (msmd) is a rare inheritance syndrome, characterized by a disseminated infection with mycobacterium in children following bcg vaccination at birth. regarding the vaccination program in iran, it may consider as a public health problem. the pathogenesis of msmd is dependent on either insufficient production of ifn-gamma (γ) or inadequate response...

Background: The effect of low dose radiation on immune system is shown. Ionizing radiation can affect cytokine production and polarization of T helper cells. Objective: The current study focused on ionizing radiation in Ukrainian children residing in a contaminated area with clinical irritable bowel syndrome. Method: Our study included 75 rural children population aged 4-18 yrs, who lived in a ...

The aim of the research was to determine differences in IL-1ß, IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α and IL-1ra blood concentrations pregnant non-pregnant healthy mares. mares were divided into two groups: (n = 18; age 6.11 ± 2.25 years); 6; 5.67 1.75 years). Blood samples collected from all 24) three times every month, then group subgroups based on pregnancy (1st 6)—6th, 7th, 8th; 2nd 6)—7th,...