نتایج جستجو برای: ایستگاه cng

تعداد نتایج: 16003  

Journal: :The EMBO journal 1999
C Dzeja V Hagen U B Kaupp S Frings

Cyclic nucleotide-gated (CNG) channels conduct Na+, K+ and Ca2+ currents under the control of cGMP and cAMP. Activation of CNG channels leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+ concentration. Several polypeptides were identified that constitute principal and modulatory subunits of CNG channels in both neurons and non-excitable cells, co...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Paul M Jenkins Lian Zhang Gary Thomas Jeffrey R Martens

Impaired ciliary protein transport in olfactory sensory neurons (OSNs) leads to anosmia, and is a newly recognized clinical manifestation of a class of human disorders called ciliopathies. Surprisingly little is known regarding the mechanisms controlling trafficking to this unique neuronal compartment. Here, we show a novel role for phosphofurin acidic cluster-sorting protein 1 (PACS-1) in the ...

2010
Shakeel Ahmad Christos Bouras Raouf Hamzaoui Andreas Papazois Erez Perelman Alex Shani Gwendal Simon George Tsichritzis

One of the most attractive features of Massively Multiplayer Online Games (MMOGs) is the possibility for users to interact with a large number of other users in a variety of collaborative and competitive situations. Gamers within an MMOG typically become members of active communities with mutual interests, shared adventures, and common objectives. We present the EU funded Community Network Game...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Juan I Korenbrot Milap Mehta Nomingerel Tserentsoodol John H Postlethwait Tatiana I Rebrik

The ligand sensitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+)-binding protein. We investigated the functional role of CNG-modulin in phototransduction in vivo in morpholino-mediated gene knockdown zebrafish. Through comparative genomic analysis, we identified the orthologue gene of CNG-modulin in zebrafish, eml1, an ancient gene present in ...

1999

We analyze alternative fuel-powertrain options for internal combustion engine automobiles. Fuel/engine efficiency, energy use, pollutant discharges, and greenhouse gas emissions are estimated for spark and compression ignited, direct injected (DI), and indirect injected (II) engines fueled by conventional and reformulated gasoline, reformulated diesel, compressed natural gas (CNG), and alcohols...

Journal: :The Biochemical journal 2012
Deborah L Duricka R Lane Brown Michael D Varnum

Mutations that perturb the function of photoreceptor CNG (cyclic nucleotide-gated) channels are associated with several human retinal disorders, but the molecular and cellular mechanisms leading to photoreceptor dysfunction and degeneration remain unclear. Many loss-of-function mutations result in intracellular accumulation of CNG channel subunits. Accumulation of proteins in the ER (endoplasmi...

2014
Agnieszka Kiliszek Wojciech Rypniewski

CNG repeats (where N denotes one of the four natural nucleotides) are abundant in the human genome. Their tendency to undergo expansion can lead to hereditary diseases known as TREDs (trinucleotide repeat expansion disorders). The toxic factor can be protein, if the abnormal gene is expressed, or the gene transcript, or both. The gene transcripts have attracted much attention in the biomedical ...

Journal: :The Journal of biological chemistry 2012
Arjun Thapa Lynsie Morris Jianhua Xu Hongwei Ma Stylianos Michalakis Martin Biel Xi-Qin Ding

Cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction. Mutations in the cone CNG channel subunits CNGA3 and CNGB3 account for >70% of all known cases of achromatopsia. Cones degenerate in achromatopsia patients and in CNGA3(-/-) and CNGB3(-/-) mice. This work investigates the molecular basis of cone degeneration in CNG channel deficiency. As cones comprise only 2-3% of...

Journal: :Fuel 2021

This paper presents an experimental study of a 4-cylinder, downsized and boosted, spark ignition engine fuelled by either directly injected compressed natural gas (DI CNG) or gasoline (GDI). Three different charge preparation strategies are investigated for both fuels: stoichiometric operation without external dilution, with exhaust recirculation (EGR) lean burn. The performance the optimized D...

Journal: :Energies 2022

Road transportation has received the attention of researchers due to its higher carbon footprint. Alternative fuels present major advantages in terms environmental sustainability. For this reason, an enviro-economic analysis alternative carries great significance. However, scarce attempts have been rendered order ascertain impact a hydroxy gas (HHO) and compressed natural (CNG) mixture on susta...

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