We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells. Treatment of cells with PMA induces COX-2 and causes a marked increase in the production of prostaglandin E2. These effects were inhibited by resveratrol. Resveratrol suppressed PMA-mediated incre...

Ribosomal protein S6 kinase activity was measured in lysates prepared from serum-deprived chicken embryo fibroblasts (CEF) treated for various times with phorbol 12-myristate 13-acetate (PMA). Maximal activity was observed within 15 min, and it declined to the initial level by 4 hr. Incubation of these cells with PMA 4-60 hr after the initial treatment did not result in an additional increase i...

Phorbolol myristate acetate (PHMA) had been previ ously prepared from the potent mouse skin tumor pro moter phorbol myristate acetate (PMA) by sodium borohydride reduction of the C-5 carbonyl group in PMA to a secondary alcohol. PHMA was shown to have an inflam matory effect in mouse skin equal to that of PMA. 2,3Dihydrophorbol myristate acetate (DPMA), a new com pound, was prepared from the 3-...

Flexible magnetic materials with robust and controllable perpendicular anisotropy (PMA) are highly desirable for developing flexible high-performance spintronic devices. However, it is still challenge to fabricate PMA films through current techniques of direct deposition on polymers. Here, we report a facile method synthesizing single-crystal freestanding SrRuO3 (SRO) membranes controlled cryst...

This paper aims to evaluate the performance of synchronous reluctance motors assisted by a permanent magnet (PMa-SynRM) focused on efficiency and torque pulsations. PMa-SynRM shows high power factor, compared induction (IM), although they have greater cost. These machines develop relatively ripple, cogging torque, imbalances. Consequently, electromagnetic is reduced, motor temperature increased...

The development of graphene oxide/rare earth complexes luminescent materials is limited due to the strong quenching ability oxide. However, hybrid with pyromellitic acid (PMA) as ligand not only have better performance, but also stronger luminescence intensity. Herein we tested effect carboxylic structure PMA on intensity materials. Phthalic (PA), Isophthalic (i-PA) and Terephthalic (p-PA) are ...

The effect of phorbol 12-myristate 13-acetate (PMA) on protein kinase C was studied by metabolically labeling GH3 cells with [35S]methionine and using a polyclonal antibody raised against rat brain protein kinase C to immunoprecipitate the enzyme. PMA accelerates the loss of immunologically reactive protein kinase C from the cells in a time- and dose-dependent manner. The half-life of the enzym...

Insulin stimulates glucose transport in isolated fat cells by activation of glucose transporters in the plasma membranes and through translocation of the glucose transporter sub-types GLUT4 (insulin-regulatable) and GLUT1 (HepG2 transporter). The protein kinase C-stimulating phorbol ester phorbol 12-myristate 13-acetate (PMA) is able to mimic partially the effect of insulin on glucose transport...

Previous studies have demonstrated an inhibition of agonist-induced inositol phospholipid breakdown and intracellular Ca2+ ([Ca2+]1) mobilization by phorbol esters in platelets. In this study, we have examined the effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced granule secretion and correlated it with agonist-induced [Ca2+], mobilization, arachidonate and thromboxane (Tx) rel...

Accurately quantifying Legionella for regulatory purposes to protect public health is essential. Real-time PCR (qPCR) has been proposed as a better method for detecting and enumerating Legionella in samples than conventional culture method. However, since qPCR amplifies any target DNA in the sample, the technique's inability to discriminate between live and dead cells means that counts are gene...