The Asp-derived amino acid pathway has been studied during the early stages of development in two maize genotypes, Io and F2, differing in germination efficiency and post-germination growth. In both genotypes expression of Ask2 (monofunctional Asp-kinase-2), Akh1 and Akh2 (bifunctional Asp-kinase-homo-Ser dehydrogenase-1 and 2), increased throughout germination and post-germination growth, sugg...

Alleles of the inducible nitric oxide synthase locus (Nos2) cosegregated highly significantly (P < 0.0001) with blood pressure in an F2 population [F2(S x MNS), n = 171] derived from a cross of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS). In contrast, alleles at the constitutive brain nitric oxide synthase locus (Nos1) did not cosegregate with blood pressure in severa...

The functional analysis of the common prothrombin 20210 G>A(F2 20210(*)A) mutation has recently revealed gain of function of 3'end processing as a novel genetic mechanism predisposing to human disease. We now show that the physiologic G at the cleavage site at position 20210 is the functionally least efficient nucleotide to support 3'end processing but has evolved to be physiologically optimal....

The functional analysis of the common prothrombin 20210 G A (F2 20210*A) mutation has recently revealed gain-of-function of 3’end processing as a novel genetic mechanism predisposing to human disease. We now show that the physiological G at the cleavage site at position 20210 is the functionally least efficient nucleotide to support 3’end processing but has evolved to be physiologically optimal...

With the recent emergence of a novel pandemic strain, there is presently intense interest in understanding the molecular signatures of virulence of influenza viruses. PB1-F2 proteins from epidemiologically important influenza A virus strains were studied to determine their function and contribution to virulence. Using 27-mer peptides derived from the C-terminal sequence of PB1-F2 and chimeric v...

Fruit extracts from black currants (Ribes nigrum L.) are traditionally used for treatment of gastritis based on seed polysaccharides that inhibit the adhesion of Helicobacter pylori to stomach cells. For detailed investigations an arabinogalactan protein (F2) was isolated from seeds and characterized concerning molecular weight, carbohydrate, amino acid composition, linkage, configuration and r...

The LiF:F2+** laser has been shown' to provide high power (hundreds ofmJ), efficient (tens of%), room temperature stable laser operation tunable from 800 nm to nearly 1210 nm. However, no reasonable explanations were provided for such an ultrabroadband tuning capability using this active medium. This work describes the mechanism ofthe ullrabroadband lasing from LiF:F2+** und Alexandrite 1asa pu...

In most common bilateral landings of vertical jumps, there are two peak forces (F1 and F2) in the force-time curve. The combination of these peak forces and the high frequency of jumps during sports produce a large amount of stress in the joints of the lower limbs which can be determinant of injury. The aim of this study was to find possible relationships between the jump height and F1 and F2, ...