Abstract Introduction: LAM is a slow growing, metastasizing neoplasm affecting women of reproductive age, marked by abnormal growth smooth muscle-like cells leading to cystic lung destruction. has hallmarks cancer, like expression immune checkpoint receptors. Effective cancer therapies promote robust T cell responses through activated dendritic (DCs). Anti-cancer strategies, toll receptor (TLR)...

هدف: کبد از حساس‌ترین بافت‌های هدف فشار اکسایشی ناشی تمرین می‌باشد و آمینوترانسفراز‌های کبدی، شاخص‌های حساسی برای تعیین آسیب دیدگی سلول‌های کبدی هستند. پژوهش حاضر با مقایسه تأثیر هشت هفته TRX مقاومتی سنتی بر برخی آنزیم‌های (آسپارتات آمینو ترانسفراز آلانین ترانسفراز) در زنان غیرفعال انجام گرفت.روش ­ها: این که به روش نیمه تجربی شد، 28 دختر میانگین سن41/1±07/21 سال شاخص توده بدن 25/4±52/22 کیلوگرم...

Plasmacytoid dendritic cells (PDC) represent a highly specialized immune cell subset that produces large quantities of the anti-viral cytokines type I interferons (IFN-alpha and IFN-beta) upon viral infection. PDC employ a member of the family of toll-like receptors, TLR9, to detect CpG motifs (unmethylated CG dinucleotides in certain base context) present in viral DNA. A certain group of CpG m...

CpG-island margins and non-island-CpG sites round the transcription start sites of CpG-island-positive and -negative genes are methylated to various degrees in a tissue-specific manner. These methylation-variable CpG sites were analyzed to delineate a relationship between the methylation and transcription of the tissue-specific genes. The level of tissue-specific transcription was estimated by ...

Ontology-based modeling of Clinical Practice Guidelines (CPG) is a well-established approach to computerize CPG for execution in clinical decision support systems. Many CPG computerization approaches use the Web Ontology Language (OWL) to represent the CPG’s knowledge, but they do not exploit its reasoning services to execute the CPG. In this paper, we present our CPG execution approach that le...

OBJECTIVES/GOALS: COPD is a progressive airways disease that results in death or disability. There poor uptake of clinical guidelines (CPG) to manage and studies bridge this implementation gap have shown inconsistent results. Using science principles we aim understand COPD-CPG determinants from providers’perspective. METHODS/STUDY POPULATION: The study being conducted ten VA Primary Care Clinic...

objective: the effect of interleukin (il)-29, a new therapeutic agent similar to type i interferons (ifns), on ifn-α secretion of human plasmacytoid dendritic cells (pdcs) has not been studied. therefore, in this study, we aimed to clarify the effect of il-29 on ifn-α secretion of pdcs using human peripheral blood mononuclear cells (pbmcs) in the presence of cytosine-phosphate-guanosinemotif-co...

Y-shape formation increased the immunostimulatory activity of phosphodiester (PO) oligodeoxynucleotides (ODNs) containing CpG motif. In this study, PO CpG ODN or CpG ODN containing nuclease-resistant phosphorothioate (PS) linkages, i.e., PS CpG ODN or PO CpG ODN with three PS linkages at the both ends (PS3), was mixed with two PO- or PS ODNs to prepare Y-shaped DNA (Y-DNA) containing a potent C...

Unmethylated cytosine-guanine dinucleotide-containing oligodeoxynucleotides (CpG ODNs), which are synthetic agonists of Toll-like receptor 9 (TLR9), activate humoral and cellular immunity and are being developed as vaccine adjuvants to prevent or treat cancers, infectious diseases, and allergies. Free CpG ODNs have been used in many clinical trials implemented to verify their effects. However, ...