this study took an epidemiological approach toward the problem of drug addiction in tehran. the subjects were 300 addicts chosen on the basis of stratified random selection out of the population of 3627 prisoners who were all proven addicts and sentenced to imprisonment by the court in the year 1370. a descriptive survey showed that drug addiction generally, and heroin addiction specifically, i...

background: glucose-6-phosphate dehydrogenase (g6pd) deficiency is one of the most known enzyme defects in iran with various genetic mutations. we aimed to study the predisposing factors of hemolysis in children with g6pd deficiency. methods: this study was done during 2007-2012 in two referral centers of mofid children's hospital and baqiyatallah hospital, tehran, iran. the hospital records of...

hypothyroidism is one of the problems that can cause severe growth and developmental defects in children and infants. by using anticonvulsive drugs (phenobarbital, carbamazepine, navalproate , and phenytoin), liver microsomal enzymes will be increased and will lead to hypothyroidism in infants because of increasing metabolism of t3, and t4 by liver. the purpose of this study was to evaluate the...

objective in this study, we investigated the changes of the serum levels of thyroidhormones including thyroxine (t4), triiodothyronine (t3), t3 resin uptake andthyroid stimulating hormone (tsh) in epileptic children during treatment withanti-epileptic drugs (aeds) including carbamazepine (cbz), primidone (prm),phenobarbital and valproic acid (vpa). materials and methods this study consisted of ...

flecainide has been known to cause torsades de pointes (tdp) in patients with structural heart disease and its mechanism has been attributed to use-dependency. we present a patient with flecainide-induced tdp in the absence of any other precipitating factors.this case highlights potential reverse use dependence associated with flecainide resulting in tdp.

despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. a large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. a variety of techniques...

pharmacists are healthcare professionals who practice in pharmacy, the field of health sciences focusing on safe and effective medication use. the role of pharmacist has shifted from the classical “lick, stick and pour” dispensary role, to being an integrated member of the health care team directly involved in patient care. but, in our country pharmacists are mainly engaged with manufacturing o...