delaminomycin A (1, Fig. 1), a novel compound possessing an acyl tetramic acid moiety1}, has been isolated from the culture broth of Streptomyces albulus MJ202-72F3 which was deposited in the Fermentation Research Institute of the Agency of Industrial Science and Technology, Japan, with the accession No. FERMP-126742). The strain also produced some compounds related to delaminomycin A as minor ...

The proliferation of Meth-A and AH6oCfibrosarcoma inoculated intraperitoneally was suppressed in all ntice given Eubacteriun lentu,tt (TYH-11) intraperitoneally. The proliferation of MH 134 hepatona and Ll2Io lytnphoitl ieukenria was also suppressed in sonte of the nice receivingthis strain. Artrongforns of solidtutnors, this bacterial strain curedsone micewith MHl34 hepanira The sunival tines ...

5beta-Methoxy (20), 14-methyl (24), 14,14-dibromo-15-nor (25), 8-O-acyl (26-45), 8-O-alkyl (46), 8-O-alkoxycarbonyl (47, 48), and 8-O-carbamoyl (49) derivatives of PA-48153C, a novel immunosuppressant isolated from fermentation products of Streptomyces prunicolor PA-48153, were prepared. These compounds were found to retain the inhibitory activity on the responses of both T and B cells to mitog...

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are target...