نتایج جستجو برای: روش eso
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PURPOSE NY-ESO-1 and LAGE-1 are homologous cancer-testis antigens, which are expressed in many different cancers. It is essential to type tumors accurately to assess patient suitability for clinical trials which target these. This study evaluates typing strategies used to distinguish these two homologous but distinct antigens and to characterize and quantitate expression of each in clinical sam...
We present the near-infrared and optical properties of the peculiar galaxy ESO 235-G58, which resembles a late-type ringed barred spiral seen close to face-on. However, the apparent bar of ESO 235-G58 is in reality an edge-on disk galaxy of relatively low luminosity. We have analyzed the light and color distributions of ESO 235-G58 in the NIR and optical bands and compared them with the typical...
tor General of ESO, Foreign Minister José Miguel Insulza and President Eduardo Frei Ruiz-Tagle. The original language version of the four addresses follows this introduction. (A translation in English of the Span-ish text is given on pages 58 and 59 in this issue of The Messenger.) A time capsule whose contents are described in Dr. Richard West's article was then deposited by President Frei wit...
We report on a large survey for double degenerate (DD) binaries as potential progenitors of type Ia supernovae with the UVES spectrograph at the ESO VLT (ESO SN Ia Progenitor surveY – SPY).
در تحقیق حاضر، یک الگوریتم ساده برای بهینه سازی ابعادی سازه های تحت کمانش ارائه شده است. روش مذکور با عنوان بهینه سازی تکاملی سازه ها(eso) بیان می شود که با در نظر گرفتن شرایط حاکم بر سازه و با رعایت اصول طراحی، مصالح سازه را باز توزیع می کند. به طور کلی هدف از انجام این پایان نامه افزایش بار کمانشی سازه و تعیین شکل بهینه آن تحت شرایط مختلف تکیه گاهی و بارگذاری می باشد. افزایش بار کمانشی با فرض...
Cancer-Testis antigens (CTA) are immunogenic molecules with normal tissue expression restricted to testes but with aberrant expression in up to 30% of non-small cell lung cancers (NSCLCs). Regulation of CTA expression is mediated in part through promoter DNA methylation. Recently, immunotherapy has altered treatment paradigms in NSCLC. Given its immunogenicity and ability to be re-expressed thr...
A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a major histocompatibility complex (MHC) class I-restricted fashion. Serological screening of cDNA expression libraries, SEREX, has recently been shown to provide another route for defining immunogenic human tumor antigens. The detection of antibody responses against known CT...
Myxoid liposarcoma is the second most common liposarcoma. Although myxoid liposarcoma is relatively chemosensitive and thus a good candidate for chemotherapy, cases with relapsed or metastatic disease still have poor outcome. Here, we performed a gene microarray analysis to compare the gene expression profiles in six clinical myxoid liposarcoma samples and three normal adipose tissue samples, a...
Recombinant poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific immune responses that will improve clinical outcome. To test whether a diversified prime and boost regimen targeting NY-ESO-1 will result in clinical benefit, we conducted two parallel phase II clinical trials of recombin...
Meningiomas are the most common primary intracranial tumors. Surgical resection remains the treatment of choice for these tumors. However, a significant number of tumors are not surgically accessible, recur, or become malignant, necessitating the repetition of surgery and sometimes radiation. Chemotherapy is rarely used and is generally not recognized as an effective treatment. Cancer/testis (C...
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