Abstract The oncological and functional outcomes in glioblastoma (GBM) patients following supratotal resection (SupTR), involving complete of contrast-enhancing enhanced (CE) tumors areas methionine (Met) uptake on 11 C-met positron emission tomography (Met-PET), are unknown. We conducted a retrospective review newly diagnosed, IDH1 wild-type GBM patients, comparing SupTR with gross total (GTR)...

Rice is considered as a major crop due to its demand globally. Pakistan famous throughout the world produce export quality rice which have healthy contribution in boosting regional economy. plant require plenty of water for proper growth and development therefore, conservation significant maintain reserves sustainable future. The main objective this study was identify day-to-day availability fi...

The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in the periodontal wound healing. Histological results from animal and human studies have shown that tr...

ESMO Clinical Practice Guidelines on high-grade gliomas dismiss impact of surgical resection on overall survival (OS) in treatment of recurrent glioblastoma (GBM), citing two pooled analyses as evidence of no effect. Neither analysis considered one critical factor in analyzing efficacy of re-resection—the extent of resection (EOR)—known to be important at first surgery. Furthermore, only 12% (3...

The TorC1 protein kinase complex is a central component in a eukaryotic cell's response to varying nitrogen availability, with kinase activity being stimulated in nitrogen excess by increased intracellular leucine. This leucine-dependent TorC1 activation requires functional Gtr1/2 and Ego1/3 complexes. Rapamycin inhibition of TorC1 elicits nuclear localization of Gln3, a GATA-family transcripti...

OBJECTIVE Suprasellar meningiomas have been resected via various open cranial approaches. During the past 2 decades, the endoscopic endonasal approach has been shown to be an option in selected patients. We wished to examine the learning curve for parameters such as extent of resection, visual outcome, and complications. METHODS We retrospectively reviewed a consecutive series of patients in ...

Einstein considered general covariance to characterize the novelty of his General Theory of Relativity (GTR), but Kretschmann thought it merely a formal feature that any theory could have. The claim that GTR is “already parametrized” suggests analyzing substantive general covariance as formal general covariance achieved without hiding preferred coordinates as scalar “clock fields,” much as Eins...

Salmonella Typhimurium isolate D23580 represents a recently identified ST313 lineage of invasive non-typhoidal Salmonellae (iNTS). One of the differences between this lineage and other non-iNTS S. Typhimurium isolates is the presence of prophage BTP1. This prophage encodes a gtrC gene, implicated in O-antigen modification. GtrC(BTP) (1) is essential for maintaining O-antigen length in isolate D...

Some patients with chronic fatigue syndrome say they benefit from taking vitamin supplements. We assessed functional status for the B vitamins pyridoxine, riboflavin and thiamine in 12 vitamin-untreated CFS patients and in 18 healthy controls matched for age and sex. Vitamin-dependent activities--aspartate aminotransferase (AST) for pyridoxine, glutathione reductase (GTR) for riboflavin, transk...