Hal incorporates a number of high-level language constructs such as the incremental specialization of synchronization constraints to maintain the consistency of actors at run-time, the inheritance of both code and synchronization constraints, and limited reeective capabilities to customize the system with respect to fault tolerance. This paper describes some issues in compiling Hal, and, in par...

We investigate the dynamics of the heterodimer autorepression loop (HAL), a small genetic module in which a protein A acts as an autorepressor and binds to a second protein B to form an AB dimer. For suitable values of the rate constants, the HAL produces pulses of A alternating with pulses of B. By means of analytical and numerical calculations, we show that the duration of A pulses is extreme...

Hal incorporates a number of high level language constructs such as the incremental special ization of synchronization constraints to maintain the consistency of actors at run time the inheritance of both code and synchronization constraints and limited re ective capabilities to customize the system with respect to fault tolerance This paper describes some issues in com piling Hal and in partic...

Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX (PpIX). The photodynamic efficacy and cell death mode after red versus blue light illumination of HAL-induced PpIX have been examined and compared using five different cancer cell lines. LED arrays emitting at 410 and 624 nm served as homogen...

Haloperidol (HAL, Fig. 1) has been used extensively as a neuroleptic for more than 40 years, and acts mainly as a blocker of dopamine D1 or D2 receptors. The metabolites of HAL include a reduced form, 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP, Fig. 1) and others. Structurally, CPHP resembles 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which induces severe neurotoxicity, including Parkinson...