OBJECTIVE Myelodysplastic syndromes (MDS) are a group of hematological neoplasms associated with ineffective hematopoiesis and that transform to acute leukemia. Distinguishing MDS from other cytopenias is sometimes difficult even for trained hematologists. WT1, the gene mutated in Wilms' tumor, was found expressed in acute myeloid leukemia and MDS. The amount of WT1 in peripheral blood and bone...

The World Health Organization (WHO) Traditional Medicine Strategy (2014-2023) aimed to help member states promote the safe and effective use of traditional medicine. While economic conditions have markedly improved in Bangladesh, the country is experiencing significant public health problems. Because of limited medical resources, there is a strong incentive to enhance complementary and alternat...

Inflammatory colorectal polyps (ICRPs) frequently occur in miniature dachshunds (MDs) in Japan. MDs with ICRPs develop multiple polyps with severe neutrophil infiltration that respond to immunosuppressive therapy. Therefore, ICRPs are thought to constitute a novel, breed-specific form of canine inflammatory bowel disease (IBD). Pattern recognition receptors (PRRs) play a key role in the distinc...

The union of two disjoint (n, 4n−1, 2) MDS codes in {0, 1, 2, 3}n is a double-MDS-code. If the adjacency graph of the double-MDS-code is not connected, then the double-code can be decomposed into double-MDS-codes of smaller lengths. If the graph has more than two connected components, then the MDS codes are also decomposable. The result has an interpretation in terms of n-quasigroups of order 4...

BACKGROUND Although hypomethylating agents (HMAs) are effective and approved therapies for patients with myelodysplastic syndromes (MDS), many patients do not benefit from treatment, and nearly all ultimately stop responding to HMAs. The incidence and cost burden of HMA failure are unknown yet needed to appreciate the magnitude and significance of such failure. METHODS We analyzed a de-identi...

Knowledge of the blast phenotype in myelodysplastic syndromes (MDS) would be valuable, as in other malignancies, but remains sparse. This is mainly because MDS blasts are a minor population in clinical samples, making analysis difficult. Thus, for this blast phenotype study, we prepared blast-rich specimens (using a new density-centrifugation reagent for harvesting blasts) from blood and marrow...

Background Immunophenotypic analysis of the bone marrow (BM) cells has proven to be helpful in the diagnosis of Myelodysplastic Syndromes (MDS). However, the usefulness of flow cytometry (FCM) for the detection of myelodysplasia in the peripheral blood (PB) still needs to be investigated. The aim of this pilot study was to evaluate the value of FCM-based PB neutrophil and monocyte immunophenoty...

Multidimensional Scaling is a useful tool to represent a nite set in an appropriate graphical display. But MDS can do much more in statistics, classiication and data analysis. It is shown in this contribution that MDS and related methods based on distances provide techniques and solutions to a wide eld of topics: distance based regression with mixed variables and non-linear regression; MDS inte...

There are various applications in wireless sensor networks which require knowing the relative or actual position of the sensor nodes. Over the past few years, there have been different localisation algorithms proposed in the literature. The algorithms based on classical Multi-Dimensional Scaling (MDS) only require 3 or 4 anchor nodes and can provide higher accuracy than some other schemes. In t...