Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, was the first ophthalmic solution developed for the treatment of glaucoma and ocular hypertension in Japan. Topical administration of K-115 decreased intraocular pressure (IOP) and increased outflow facility in rabbits. This study evaluated the effect of K-115 on monkey tra...

Spontaneous and mutagen induced sister chromatid exchange (SCE) frequencies have been studied in nine patients with multiple sclerosis and in nine age and sex matched healthy controls. The incidence of spontaneous SCE in lymphocytes of the MS patients was significantly greater, by about 50%, than in those of the control subjects. When exposed to mitomycin C (MMC) or ethyl methane sulfonate (EMS...

The frequency of sister chromatid exchange (SCE) was analyzed in bone marrow cells of 16 patients with chronic myeloid leukemia. We have compared the SCE frequency in these patients, in both chronic and blastic phases of the disease, to that of normal individuals. The frequency of SCE in blastic-phase chronic myeloid leukemia patients (mean, 1.86/cell) was significantly lower than that in chron...

OBJECTIVES To determine students' ability to discriminate benign vs malignant lesions and to assess attitudes regarding skin cancer examination (SCE). DESIGN Second-year medical students at 1 institution participated in an SCE intervention for 2 consecutive years. INTERVENTION Cohort 1 received intervention A, consisting of SCE teaching without a dermoscopy tutorial. Cohort 2 received inter...

Zero-liquid discharge wastewater treatment driven by sunlight shows potential to minimize its environmental impact producing solid-only waste from solar energy. To overcome the key barrier of absorber contamination, solar-driven contactless evaporation (SCE) has been proposed. However, only a small-scale laboratory device studied, which cannot support scalable application. analyze SCE, it is es...

The study was aimed at evaluating the frequency of spontaneous sister chromatid exchange in Polish White Improved goats (Capra hircus). The mean number of SCEs/cell was 2.73 +/- 1.84. The effect of sex and age on SCE incidence was also investigated. No statistically significant differences in the number of SCEs/cell were observed between the males and females. On the other hand, age was found t...

This paper introduces the Spectral Clustering Equivalence (SCE) algorithm which is intended to be an alternative to spectral clustering (SC) with the objective to improve both speed and quality of segmentation. Instead of solving for the spectral decomposition of a similarity matrix as in SC, SCE converts the similarity matrix to a columncentered dissimilarity matrix and searches for a pair of ...

Many claims about political behavior are based on implicit assumptions about how people think. One such assumption, that political actors use identical conjectures when assessing others’ strategies, is nested within applications of widely-used game theoretic equilibrium concepts. When empirical research calls this assumption into question, the self-confirming equilibrium (SCE) concept is an alt...

Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion is not the only determinant of replicative capacity; instead, T-SCE need to be...

Artificial intelligence (A_r) has been looking for a "killer applieation" since its ineeption. Now, with the world wide web, intranets, intelligent agents, and the emerging knowledge management trends, AI may have found its much needed killer application. Through the use of web-based intelligent agent technology, knowledge management systems ean be developed in very effeetive ways. This paper w...