OBJECTIVES Health Avatar Beans was for the management of chronic kidney disease and end-stage renal disease (ESRD). This article is about the DialysisNet system in Health Avatar Beans for the seamless management of ESRD based on the personal health record. METHODS For hemodialysis data modeling, we identified common data elements for hemodialysis information (CDEHI). We used ASTM continuity o...

BACKGROUND AND OBJECTIVES Imatinib mesylate induces a complete cytogenetic response (CCR) in many patients with chronic myeloid leukemia (CML). However, the ultimate goal of therapy for CML is complete elimination of Philadelphia chromosome positive cells or BCR-ABL rearrangements. We studied molecular responses in CML patients in CCR after imatinib treatment. DESIGN AND METHODS Real-time qua...

BACKGROUND Measures assessing quality of life (QOL) in patients participating in comprehensive cardiac rehabilitation (CCR) have not been established in Japan. METHODS AND RESULTS To compare different types of QOL scales and to determine the impact of CCR on QOL in Japanese cardiac patients, 5 different types of questionnaires were assessed in 44 patients participating in CCR after acute myoc...

BACKGROUND Interferon-alpha (IFN) induces complete cytogenetic remission (CCR) in 20-25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from proteinase 3 and neutrophil elastase, but it is unknown how CCR persists after IFN is stopped. ...

Anniversary This year marks a milestone for Clinical Cancer Research (CCR)—we are celebrating our 20 th anniversary. CCR was launched in January 1995 by the American Association for Cancer Research (AACR), and at the time it was the third journal to join AACR's family of publications (following Cancer Research and Cancer Epidemiology, Biomarkers & Prevention). The journal was launched to report...

recurr moso spann the N tified (10 p gain). each o 2 case sampl reduc hetero of 10 NF1 e numb NF1 e NF protei impor Activa appro cytic leuke mato have marke ing m sine p presen activa his issue of Clinical Cancer Research, Parkin and gues report on the identification of a subset of adult myelogenous leukemia (AML), in which the tumor essor NF1 is functionally inactive, resulting in ind Ras sign...

BACKGROUND Although endogenous creatinine clearance is often used as an indicator for the glomerular filtration rate (GFR), it may result in an overestimation due to its tubular secretion. Since cimetidine is known to inhibit tubular secretion of creatinine, it may improve the accuracy of the creatinine clearance in measuring GFR. METHODS Creatinine clearance (Ccr) was compared with iothalama...

It has been shown that certain chemokine receptor polymorphisms may correspond to certain complications after organ transplantation. Ischemic-type biliary lesion (ITBL) encounters for major morbidity and mortality in liver transplant recipients. So far, the exact cause for ITBL remains unclear. Certain risk factors for the development of ITBL like donor age and cold ischemic time are well descr...

Cyclocreatine (CCr), a substrate analogue of creatine kinase (CK), exhibits antitumor activity in vitro and in vivo. To address its mechanism of action, we have examined its effects on tumor cell proliferation, viabil ity, and cell cycle progression. Complete inhibition of proliferation of ME-iSO cervical carcinoma cells was observed within S h of exposure to CCr and was characterized by an inh...