BACKGROUND The association between high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) events is not well described in individuals with very high levels of HDL-C (>80 mg/dL). METHODS AND RESULTS Using pooled data from 6 community-based cohorts we examined CHD and total mortality risks across a broad range of HDL-C, including values in excess of 80 mg/dL. We used Cox ...

Methods We investigated adiponectin receptor 1(AdipoR1) gene rs10920533 associated with non-HDL-C(case: 109 subjects with high non-HDL-C; control: 701 subjects with normal non-HDL-C); apolipoprotein A5(ApoA5) gene -1131T>C and -3A>G associated with TG(case: 245 subjects with high TG; control: 595 subjects with normal TG); glucocorticoid receptor(GR) gene rs12521436 associated with HDL-C(case: 1...

Abstaract: Objective: To investigate whether the risk profile for coronary heart disease (CHD) is more favorable in individuals with high tetraplegia (neurological lesion above C4) than in healthy controls. (Because inactivity has a negative effect on the lipid profile.) Design: Case-control study. Setting: This research was performed in the rehabilitation hospital for the spinal cord injured p...

High-density lipoprotein (HDL) is highly heterogeneous in its size and composition. Till now, the link of HDL subfractions to coronary risk is less clear. We aimed to investigate the associations of HDL subfractions with traditional risk factors (RFs), coronary severity, and outcomes in a cohort of nontreated patients with stable coronary artery disease (CAD). We prospectively enrolled 591 elig...

OBJECTIVE Summarizing the many discovered mouse and human quantitative trait loci (QTL) for high density lipoprotein (HDL) cholesterol (HDL-C) levels is important for guiding future research on the genetic regulation of HDL concentrations and for finding gene targets for upregulating HDL levels in mice and humans. METHODS AND RESULTS We summarized the 27 QTL and candidate genes associated wit...

BACKGROUND AND OBJECTIVES The clinical significance of statin-induced high-density lipoprotein cholesterol (HDL-C) changes is not well known. We investigated whether rosuvastatin-induced HDL-C changes can influence the anti-oxidative action of high-density lipoprotein particle. SUBJECTS AND METHODS A total of 240 patients with stable ischemic heart disease were studied. Anti-oxidative propert...

Low HDL-cholesterol (HDL-C) concentrations are inversely correlated with cardiovascular disease, and previous studies have demonstrated that variants in the ATP-binding cassette transporter, ABCA1, are responsible for a proportion of HDL-C deficiency states. We identified a novel variant in ABCA1 in a kindred with decreased HDL-C. This variant was not identified in >200 chromosomes of healthy i...

The objective of this study was to investigate serum lipoprotein levels in order to assess cardiovascular disease (CVD) risk factors between fish-consuming populations and non-fish-consuming populations, as it has been speculated that fish intake reduces CVD risk. A representative sample of one thousand subjects (529 men and 471 women) were selected, with ages ranging from 20 to 70 years, from ...