RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the C. elegans zygote, germline RNA granules, called P granules, assemble preferentially in the posterior cytoplasm. We present evidence that P granule asymmetry...

Electro- and magnetoencephalography (EEG/MEG) are the means to investigate the dynamics of neuronal activity non-invasively in the human brain. However, both EEG and MEG are also sensitive to non-neural sources, which can severely complicate the interpretation. The saccadic spike potential (SP) at saccade onset has been identified as a particularly problematic artifact in EEG because it closely...

PURPOSE To evaluate the effectiveness of surgery for epilepsy, we analyzed rhythmic fast activity by magnetoencephalography (MEG) before and after surgery using time-frequency analysis. To assess reliability, the results obtained by pre-surgical MEG and intraoperative electrocorticography were compared. METHODS Four children with symptomatic localization-related epilepsy caused by circumscrib...

Interictal MEG dipoles associated with temporal lobe epilepsy (TLE) can be classified according to localization and orientation into anterior temporal horizontal (ATH), anterior temporal vertical and posterior temporal vertical (PTV) dipoles [1, 2, 3]. The MEG dipole pattern may be related to the seizure onset zone [2, 3] or symptomatology [4]. These dipoles are considered to originate from the...

Electroencephalography (EEG), magnetoencephalography (MEG), and intracerebral stereotaxic EEG (SEEG) are the three neurophysiological recording techniques, which are thought to capture the same type of brain activity. Still, the relationships between non-invasive (EEG, MEG) and invasive (SEEG) signals remain to be further investigated. In early attempts at comparing SEEG with either EEG or MEG,...

This technical report has been submitted for review and possible publication in a journal. Because changes may be made before publication, this document is made available with the understanding that any journal version supersedes this document. Until such journal publication occurs, please cite this work using the above technical report number. Magnetoencephalography (MEG) and electroencephalog...

SAM (synthetic aperture magnetometry) and MUSIC (multiple signal classification) are methods for identifying dipolar sources represented in the covariance of MEG measurements. SAM operates by estimating source and noise power, as a function of position and current vector, from a full-rank covariance matrix [1]. MUSIC finds the locations for which a test dipole is orthogonal to the covariance no...

Magnetoencephalography (MEG) is a useful non-invasive technique for presurgical evaluation of focal cortical dysplasia patients. We aimed at clarifying the precise spatial relationship between the spiking volume determined with MEG, the seizure onset zone and the lesional volume in patients with focal cortical dysplasia. We studied the spatial relationships between the MEG spiking volume determ...

Modern neuroimaging techniques enable non-invasive observation of ongoing neural processing, with magnetoencephalography (MEG) in particular providing direct measurement of neural activity with millisecond time resolution. However, accurately mapping measured MEG sensor readings onto the underlying source neural structures remains an active area of research. This so-called "inverse problem" is ...