Methods A single-center cohort study of all consecutive patients <18 years of age with biopsy proven LN diagnosed in 1980–2006 was performed. Self-designated ethnicity, clinical and laboratory features including renal function, urinalysis and overall activity (SLEDAI) were recorded. Associations of ethnicities, LN subtypes, clinical and laboratory variables were tested using chi-squared analysi...

Methods Thirty-six adolescents with SLE were evaluated to determine the characteristics of the disease. SLE disease activity index (SLEDAI) was used to assess SLE status. Beside routine laboratory investigations of SLE, measurement of follicle stimulating hormone(FSH), leutinizing hormone (LH) and estrogen (E2) for females or testosterone for males before and 4 hours after LH releasing hormone ...

Methods We launched a non-interventional study with analysis of clinical, biological and pharmacokinetic information. Full-PK profiles of MPA were modelled using an iterative two-stage approach (1). The clinical status was defined by the SLEDAI, the SLE being considered active for a score ≥6. Relationships between MPA through concentrations (C0), AUC (Area Under Curve) or AUC/ dose values, and ...

Background Cachexia plays an important role in rheumatoid arthritis (RA), due to its chronic inflammatory process characterized by decreased muscular mass with preservation or increase of fat that occurs 1-13% the RA population. A BMI has a paradoxical relationship disease activity, activity and mortality (1). Systemic lupus erythematosus (SLE) is autoimmune production nuclear autoantibodies ca...

Methods Retrospective chart review of the clinical, laboratory, and radiographic features of SLE patients diagnosed before the age of 18 and followed at MSCHONY/CUMC in 2007-2009. Disease activity (SLEDAI) at diagnosis, occurrence of major infections, and Systemic Lupus International Collaborating Clinics Damage Index (SLICC) were evaluated. NPSLE was defined according to American College of Rh...

Methods 34 cSLE patients (study group), 51 with other rheumatic or autoimmune diseases and 26 healthy children (control groups) were studied. For evaluating the disease activity, SLEDAI and ECLAM scores were used. For estimating the disease severity the criteria were: involvement of 3 vital organs (kidneys or CNS or blood or combination of ≥2 organs), increased anti-dsDNA titres, low C3 /C4 con...

Methods Forty-three JSLE patients (revised ACR criteria, mean age = 14.3 yrs, 36F:7M), and 35 age and gender matched healthy controls were studied; 30 JSLE had SLEDAI score 4, reflected active disease. Soluble molecules were measured by commercial ELISA kits. Lymphocytes and monocytes were stained with specific moAbs and analyzed by flow cytometry. Kruskal-Wallis test and Spearman’s rank were e...

at present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsdna antibodies), erythrocyte sedimentation rate (esr), levels of c-reactive protein (crp), or cytokines such as il-2/il-2 receptor, il-6 and il-10 are used as indirect serological markers with variable degrees of significance. to date, no specific ...

Methods Analytic descriptive study. 89 patients with diagnosis SLE (1986 ACR criteria) from a rheumatology center at a pediatric hospital were evaluated at the time of diagnosis and twelve months after. Medical records were reviewed registering the following variables: score SLEDAI, Antinuclear antibodies (ANAs), Anti-DNA antibodies and complement C3 and C4 levels. Analysis was done through par...

Objectives: To validate the SIMPLE index for systemic lupus erythematosus (SLE) disease activity assessment in Chinese patients. Methods: Adult patients (age ≥18 years) who fulfilled 2013 SLICC criteria SLE and were followed Rheumatology clinics of Tuen Mun Hospital, Hong Kong recruited a cross-sectional study. Participants invited to complete questionnaire before seeing doctors on same day. Th...